objective To promote the efficient and extensive application of clinical pathway information, to play the role of clinical pathway as a medical quality control and management tool, to ensure medical security, to improve the homogenization level of medical service quality, and to gradually improve proportion clinical pathway discharges accounting for over 50% of the total number of hospital discharges.Methods Information based clinical pathway was redesigned, in the mean time, key nodes of the information based clinical pathway were reconstructed under new operational mode, realtime indicators of the pathway execution rate were added, and as a result, complete information based supervision was gradually realized.Results The number of demographics of diseases under clinical pathway increased from 78 categories in 2017 to 328 categories in May 2018. The population of digital clinical pathway completed accounted for nearly 50% of the hospital discharges from January to May 2018. Four diseases (removal of internal fixation device of fracture patients, nasal fracture, ureteral calculi, and large intestine polyps) were selected out of 9 diseases for the decrease in average hospitalization period, average expense per head, average pharmaceutical expense per head, and average pharmaceutical percentage. The 2.0 version of the clinical pathway was statistically different from the nondigital clinical pathway (Ｐ<0.05).Conclusion The standardized digital clinical pathway has shortened the average hospitalization period to a large extent, reduced medical expenses, standardized medical treatment to the greatest extent, and will play a greater role in future hospital management.