Changes of hemoglobin in the treatment of moderate and severe traumatic brain injury by hyperbaric oxygenation combined with progesterone and prognostic relevance
Jin Menghao1,Wu Lijun2,Sun Mengfang1,Wang Feng1,Wu Tingqian1,Xu Qiang1
1 Department of Neurosurgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, 325000, China; 2 Department of Laboratory, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine
Abstract：Objective To study the effects of hyperbaric oxygenation combined with progesterone on hemoglobin and prognosis in moderate and severe traumatic brain injury. Methods Ninety patients with moderate and severe traumatic brain injury (TBI) from January 2016 to June 2016 were randomly divided into three groups. Hyperbaric oxygenation, progesterone, and hyperbaric oxygenation combined with progesterone treatment were used respectively in three groups. We compared changes of progesterone, estradiol and testosterone in the serum, Glasgow coma (GCS) score, and Glasgow prognosis (GOS) score among groups. Results After the treatment, the levels of progesterone and estradiol in hyperbaric oxygenation combined with progesterone group were significantly higher than those in progesterone group and hyperbaric oxygenation group, while testosterone level was significantly lower than that in progesterone group and hyperbaric oxygenation group, with significant difference (P<0.05). After the treatment, the GCS score in hyperbaric oxygenation combined with progesterone group was significantly higher than that in progesterone group and hyperbaric oxygenation group, and the difference was significant (P<0.05). In the six-month follow-up, the GOS score in hyperbaric oxygenation combined with progesterone group was significantly higher than that in progesterone group and hyperbaric oxygenation group, with significant difference (P<0.05). Conclusion Hyperbaric oxygenation combined with progesterone can effectively improve the levels of progesterone and estradiol, decrease the testosterone level, and improve prognosis for the treatment of moderate and severe TBI.
金孟浩, 吴丽君, 孙孟坊, 王丰, 吴挺前, 徐强. 高压氧联合黄体酮治疗中重度创伤性脑损伤后血性激素的变化及预后分析[J]. 中国医院统计, 2017, 24(5): 329-331.
Jin Menghao, Wu Lijun, Sun Mengfang, Wang Feng, Wu Tingqian, Xu Qiang. Changes of hemoglobin in the treatment of moderate and severe traumatic brain injury by hyperbaric oxygenation combined with progesterone and prognostic relevance. journal1, 2017, 24(5): 329-331.
