Abstract：Objective To explore allergen characteristic and clinical detection meaning of children asthma. Methods With case-control study method, 135 children with asthma and 140 healthy children through physical examination were respectively accepted questionnaire investigation, skin prick test and serum allergen detection. The positive rates of inhaled allergens and food allergens, family history of asthma and history of hypersensitivity disease, IgE positive rate of serum were compared between the two groups. Results The positive rates of allergen such as dust mite, pollen, cat dog dander, plumery, Blattella germanica, milk, egg white and flesh in the asthma group were much higher than those of the control group (P<0.05). Multiple factors analysis result showed that these factors of family history of allergy (OR=3.662), history of asthma of first-degree relative (OR=8.388), history of asthma of second-degree relative (OR=5.775), allergic rhinitis history (OR=5.569), drug allergy history (OR=7.942) and eczema history (OR=6.716) in the asthma group were much higher than those of the control group (P<0.01). The positive rates of TIgE and SIgE in the asthma group were respectively 48.1% and 65.2%, both much higher than those of the control group (22.9% and 27.1%, both P<0.01). Conclusion The influencing factors of asthma include family history of asthma, family history of allergy, eczema history, inhaled allergens and food allergens. Skin prick test and serum IgE detection play an important role in detecting allergen of children asthma.
