Abstract：Objective The aim of this study is to assess the associated factors of Henoch-Schonlein purpura(HSP) in Chinese children. This study has important public implications for developing strategies of preventing HSP. Methods In this hospital-based, case-control study, we recruited 353 HSP cases and 61 control participants during 2012 and 2015. We collected related information of 414 HSP in children and the control group through questionnaires. Student′s t-test, Pearson Chi-square test and Wilcoxon test were used respectively to compare the difference between the case and control group; We applied logistic regression model to analyze the associated factors of HSP in children. Results Univariate analysis revealed that the differences in age, mother and father′s level of education were significant between the case and control group. Univariate analysis also revealed that the differences in diet regularity, eating cold, fried and spicy food, meat, drinks, milk and dairy products, fruits and vegetables between the two groups were statistically significant. Similarly, the differences in way of birth, breast-feeding, mixed feeding and mother contacting harmful substances before becoming pregnant between the two groups were statistically significant. After the adjustment of age, sex and mother′s level of education, multivariate Logistic regression demonstrated that living in rural areas, the enough sleep time, consumption frequencies of fruit, sweet and meat and mother′s level of education were protective factors for HSP in children. Multivariate Logistic regression also demonstrated that mixed feeding, feeding after chewing, illness during pregnancy, and consumption frequencies of cold, spicy food and nuts were the risky factors for HSP. Conclusion Sufficient sleep time, less cold and spicy food and plenty of meat and fruit can reduce the risk of HSP in children. Advocating breastfeeding, avoid feeding after chewing can also prevent children from HSP.
谢彪，曲思杨，相静，罗潇，王文佶，刘美娜. 基于logistic回归模型的儿童过敏性紫癜影响因素研究[J]. 中国医院统计, 2015, 22(5): 333-337.
Xie Biao, Qu Siyang, Xiang Jing, Luo Xiao, Wang Wenji, Liu Meina. Influencing factor study of Henoch-Schonlein purpura in children based on the logistic regression model. journal1, 2015, 22(5): 333-337.
[1] 中华医学会儿科学分会肾脏病学组.儿童常见肾脏疾病诊治循证指南(二):紫癜性肾炎的诊治循证指南[J].中华儿科杂志,2009,47(12):2. [2] Avner ED, Harmon WE, Niandet P. Pediatric Nephrology[M]. Lippincott WiHiams and Wikins, 2004:851-864. [3] Penny K, Fleming M, Kazmierczak D, et al. An epidemiological study of Henoch-Schonlein purpura[J]. Paediatric nursing, 2010,22(10):30-35. [4] Dolezalova P, Telekesova P, Nemcova D, et al. Incidence of vasculitis in children in the Czech Republic: 2-year prospective epidemiology survey[J]. The Journal of rheumatology, 2004,31(11):2295-2299. [5] Trnka P. Henoch-Schonlein purpura in children[J]. Journal of paediatrics and child health, 2013,49(12):995-1003. [6] 吴丽娟.免疫球蛋白及补体水平变化对过敏性紫癜患儿临床表现的影响[J].社区医学杂志,2012,20(10):22-23. [7] 李强翔,文格波,颜向军,等.氨基胍和维生素C对糖尿病大鼠免疫功能影响的实验研究[J].实用预防医学,2005,12(1):80-82. [8] 刘秀英,胡怡秀,胡余明,等.蛋白质粉增强免疫力实验研究[J].中国热带医学,2009,9(2):249-250. [9] 董晓慧,安立新,关媛媛,等.儿童与成人特应性疾病影响因素分析[J].中国公共卫生,2014,30(11):1411-1414. [10]赵晶,所佳宁,罗潇,等.基于零膨胀模型的阳性过敏原数影响因素研究[J].中国卫生统计,2014,31(5):853-859. [11]赵玉霞,马晓春,于润江.沈阳地区过敏原皮肤试验结果的城乡对比分析[J].中国公共卫生,1999,15(9):775-776. [12]Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization[J]. Allergy, 2005, 60(11):1357-1360. [13]Dagoye D, Bekele Z, Woldemichael K, et al. Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia[J]. American journal of respiratory and critical care medicine, 2003, 167(10):1369-1373. [14]郑莹,尚启祥,王雨秋,等.母乳喂养与人工喂养对新生儿免疫功能的影响[J].中华妇产科杂志,1995,30(10):584-587. [15]Patel SR,Hu FB. Short sleep duration and weight gain:A systematic review[J]. Obesity, 2008,16(3):643-653. [16]Wang MF. Sleep quality and immune mediators in asthmatic children[J]. Pediatrics and neonatology, 2009,50(5):222-229. [17]温煦,许世全.睡眠时间、身体活动水平与肥胖的关系初探[J].中国运动医学杂志,2009,28(4):367-371. [18]方今女,南光日,崔莲花,等.青少年肥胖与父母社会经济状况关系的研究[J].现代预防医学,2002,29(6):747-749. [19]Lusi E A, Di Ciommo V M, Patrissi T, et al. High prevalence of nickel allergy in an overweight female population: a pilot observational analysis[J]. Plos one, 2015,10(3):1-9. [20]程英惠,曹文成,罗彦,等. 307例新生儿出生体重影响因素的研究[J].公共卫生与预防医学,2012,23(2):54-57.
