Abstract：Objective To explore the relapse rate and correlated risk factors of bladder carcinoma after operation. Methods One hundred and fifty-eight patients with bladder carcinoma operation were divided into relapse group and without-relapse group, through 3 years following-up. Correlated risk factors that could affect relapse after operation were collected, and risk factors were screened by single factor and multiple factors analysis methods. Results The relapse rate of bladder carcinoma after 3 years′ operation was 26.6 percent (42/158). Single factor analysis showed that the factors of tumor grading, tumor staging, tumor size, tumor amount, operation styles, lymphatic metastasis and adjuvant chemotherapy after operation affected the relapse of bladder carcinoma after operation. Multiple factors analysis results showed that the risk factors of bladder carcinoma after operation included in tumor grading (OR=2.632), tumor staging (OR=2.690), operation styles (OR=2.936) and lymphatic metastasis (OR=9.935), but adjuvant chemotherapy after operation was the protective factor of bladder carcinoma after operation. Conclusion The independent risk factors of bladder carcinoma after operation include muscle invasive bladder cancer, higher tumor grading or staging of tumor, partial cystectomy, incidence of lymphatic metastasis and adjuvant chemotherapy after operation.
[1] 路璐,李小顺,何丽萍,等.膀胱癌膀胱全切术后尿道复发的危险因素分析及干预研究[J].中中华临床医师杂志:电子版, 2014,8(18):3240-3242. [2] Boorjian SA, Kim SP, Weight CJ, et al. Risk factors and outcomes of urethral recurrence following radical cystectomy[J]. Eur Urol, 2011,60(6):1266-1272. [3] 徐俊,扬凯.膀眺癌术后患者预后影响因素调查研究[J].中国现代医生,2013,51(2):7-8. [4] 邓景球,郑志涛,向民,等.膀胱局限性浸润癌保留膀胱综合性治疗[J].中国当代医药,2012,19(7):27-28. [5] 舒辉.选择性膀胱部分切除术对浸润性膀胱癌预后的影响因素[J].实用癌症杂志,2014,29(6):705-708. [6] 那彦群,叶章群,孙光.2011版中国泌尿外科疾病诊断治疗指南[M].北京: 人民卫生出版社,2011,16-46. [7] 何建华,舒跃民.浅表性膀胱癌术后复发和进展影响因素分析[J].中国基层医药,2009,16(10):1743-1744. [8] 付水,毕缓,穆中一.浸润性膀胱癌根治术预后相关因素分析[J].中国基层医药,2012,19(10):1495-1496. [9] 房杰群,黄建生,肖克峰.膀胱部分切除术配合辅助化疗治疗盆腔淋巴结阴性的肌层浸润性膀胱癌临床疗效及其预后影响因素分析[J].国际泌尿系统杂志,2014,34(4):468-471. [10]朱延军,王国民,徐志兵,等.膀胱癌患者行保留膀胱手术后复发的危险因素分析[J].复旦学报,2014,41(6):742-746. [11]Hugen CM, Polcari AJ, Fitzgerald MP, et a1. Risk factors for recurrence following radical cystectomy for pathologic node negative bladder cancer[J]. J Surg Oncol, 2010,102(4):334-337. [12]Lammers RJ, Witjes wP, Hendrieksen K, et a1. Smoking status is a risk factor for recurrence after transurethral resection of non-muscle-invasive bladder cancer[J]. Eur Urol, 2011,60(4):713-720. [13]Yamanaka K, Miyake H, Hara I, et a1. Significance of radical cystectomy for bladder cancer in patients over 80 years old[J]. Int Urd Nephrel, 2007,39(1):209-214.
