2型糖尿病患者急性冠心病事件发病风险的回顾性队列研究

doi:10.3969/j.issn.1006-5253.2024.02.003

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摘要目的分析2型糖尿病患者急性冠心病事件的发病风险，为糖尿病患者管理提供依据。方法基于温州市慢性病协同管理系统数据进行回顾性队列研究，277 205例2010—2020年诊断的新发2型糖尿病患者纳入分析，通过身份证号与急性冠心病事件监测库和死亡监测数据库进行匹配，获得冠心病发病和死亡信息。采用Cox风险回归模型分析糖尿病患者确诊时并发症情况与急性冠心病事件发病风险的关联。结果随访期间共有3 241例2型糖尿病患者发生急性冠心病事件，冠心病发病率为1 169.17/10万。1 083名糖尿病患者因冠心病死亡，病死率390.69/10万。以糖尿病患者确诊时无并发症为参照，1个并发症和2个及以上者冠心病发病风险HR分别为1.382(95%CI：1.266～1.508)和1.661(95%CI：1.221～2.259)。结论 2型糖尿病患者急性冠心病事件的发病和死亡风险较高，在患者管理中应加强干预，积极防治并发症发生。

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	樊丽辉
	姜雪霞
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	罗永园

关键词 ： 2型糖尿病, 冠心病, 队列研究

Abstract：Objective To analyze the risk of acute coronary events in patients with type 2 diabetes mellitus, and to provide basis for the management of patients.Methods Based on the data of Wenzhou chronic disease collaborative management system, a retrospective cohort study was conducted. A total of 277 205 newly diagnosed type 2 diabetes mellitus patients from 2010 to 2020 were included in the analysis. The incidence and death information were obtained by matching the ID number with the data of acute coronary events and deaths. COX regression model was used to analyze the relationship between the complications of diabetes patients at the time of diagnosis and the risk of acute coronary events.Results During the followup period, acute- coronary events occurred in 3 241 cases, and the incidence rate of coronary heart disease was 1 169.17/100 000; 1 083 diabetes patients died from coronary heart disease, with a fatality rate of 390.69/100 000. Taking the patients diagnosed without complications as the reference, the HR of acute coronary disease in patients with one complication and two or more was 1.382 (95%CI:1.266-1.508) and 1.661 (95%CI:1.221-2.259) respectively.Conclusion Type 2 diabetes patients have a high risk of morbidity and mortality from acute coronary events , so intervention should be strengthened in patient management to actively prevent and treat complications.

Key words： type 2 diabetes mellitus acute coronary event cohort study

收稿日期: 2023-12-26

基金资助:温州市科技局项目（Y20210383）

通讯作者: 通信作者：樊丽辉，Email：610643926@qq.com

引用本文:

樊丽辉，姜雪霞，郑宇航，叶振淼，罗永园. 2型糖尿病患者急性冠心病事件发病风险的回顾性队列研究[J]. 中国医院统计, 2024, 31(2): 90-94.
Fan Lihui, Jiang Xuexia, Zheng Yuhang, Ye Zhenmiao, Luo Yongyuan. Retrospective cohort study on risk of acute coronary events in patients with type 2 diabetes mellitus. journal1, 2024, 31(2): 90-94.

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［1］RISK FACTOR COLLABORATION (NCD-RISC) N C D. Worldwide trends in diabetes since 1980:A pooled analysis of 751 population-based studies with 4.4 million participants［J］. Lancet, 2016,387(10027):1513-1530. DOI: 10.1016/S0140-6736(16)00618-8.

［2］国家卫生健康委疾病预防控制局.中国居民营养与慢性病状况报告:2020年［M］.北京:人民卫生出版社,2021.

［3］OIKONOMOU E, TSIGKOU V, LAZAROS G, et al. The interaction between gender and diabetes mellitus in the coronary heart disease risk［J］. Curr Pharm Des, 2016,22(25):3802-3816. DOI: 10.2174/1381612822666160606202111.

［4］丁怡敏,孙捷.糖尿病冠心病的临床特征及防治［J］.中国社区医师(综合版),2006,8(3):9.

［5］EMERGING RISK FACTORS COLLABORATION, SARWAR N, GAO P, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies［J］. Lancet, 2010,375(9733):2215-2222. DOI: 10.1016/S0140-6736(10)60484-9.

［6］郑天圣,佟雪巍,张伊桐,等.2型糖尿病心血管并发症发病机制的研究进展［J］.基础医学与临床,2022,42(5):814-817.DOI: 10.16352/j.issn.1001-6325.2022.05.008.

［7］孙一鑫,周一帆,程吟楚,等.阿卡波糖与2型糖尿病患者冠心病发病风险的回顾性队列研究［J］.药物流行病学杂志,2018,27(10):663-668.DOI: 10.19960/j.cnki.issn1005-0698.2018.10.006.

［8］林兰,杨钧,胡东鹏.糖尿病冠心病临床特点和防治策略［C］//第六次全国中西医结合糖尿病学术会议论文汇编.北京:中国中西医结合学会糖尿病专业委员会,2002.

［9］武海滨,胡如英,龚巍巍,等.2010至2012年浙江省25岁及以上居民急性冠心病事件监测［J］.中华心血管病杂志,2015,43(2):179-183.DOI: 10.3760/cma.j.issn.0253-3758.2015.02.024.

［10］李思瑜,林海江,王良友,等.台州市四类慢性非传染性疾病报告发病率分析［J］.预防医学,2017,29(2):177-179.DOI: 10.19485/j.cnki.issn1007-0931.2017.02.020.

［11］汪进洋,刘明涛.2016—2020年东营市东营区20岁及以上居民冠心病发病率变化趋势及类型分析［J］.预防医学论坛,2022,28(7):526-529.

［12］李建新,李莹,刘芳超,等.中国≥40岁糖尿病患者的心血管疾病风险［J］.中华心血管病杂志,2020,48(11):968-974.DOI: 10.3760/cma.j.cn112148-20191203-00733.

［13］赵莼,张巧,徐淑静,等.贵阳城区40岁以上中老年人群不同糖代谢状态与心血管疾病风险相关性研究［J］.中华内分泌代谢杂志,2018,34(8):643-648.DOI: 10.3760/cma.j.issn.1000-6699.2018.08.004.

［14］KNOWLTON A A, LEE A R. Estrogen and the cardiovascular system［J］. Pharmacol Ther, 2012,135(1):54-70. DOI: 10.1016/j.pharmthera.2012.03.007.

［15］蒋艺兰,鲍家军,朱蓓,等.2型糖尿病合并冠心病的相关危险因素分析［J］.南通大学学报(医学版),2020,40(6):577-578.DOI: 10.16424/j.cnki.cn32-1807/r.2020.06.026.

［16］李英华,李莉,聂雪琼,等.中国6省糖尿病患者糖尿病慢性并发症自报率及影响因素研究［J］.中国健康教育,2014,30(1):3-6.DOI: 10.16168/j.cnki.issn.1002-9982.2014.01.021.

［17］徐冰冰,李肖静,张亚伟.2型糖尿病患者糖尿病慢性并发症现状调查及影响因素［J］.华南预防医学,2021,47(1):74-76.DOI: 10.12183/j.scjpm.2021.0074.

［18］刘家明,孔德平,林海玲.某社区糖尿病慢性并发症影响因素分析［J］.中国医院统计,2018,25(5):333-334.DOI: 10.3969/j.issn.1006-5253.2018.05.005.

［19］李宁,来丽萍,李亮,等.2010—2018年潍坊市急性冠心病死亡率及变化趋势分析［J］.现代预防医学,2020,47(16):2925-2928.

［20］曾士典,邵永强,张娜.2016年温州居民健康状况评价报告［M］.杭州:浙江科学技术出版社,2017.