Abstract:Objective To understand the basic characteristic analysis, composition and changes of death causes of inpatient deaths in a tertiary public hospital.Methods The medical record information retrieval system of the hospital was used to sort and analyze the data of age, gender, and main diagnosis of in-hospital deaths.Results From 2013 to 2020, there were 184 052-discharged patients and 563 hospitalized deaths, with a total case fatality rate of 3.06‰; the fatality rate of males was high than that of females and the difference was statistically significant (χ2=95.329, P<0.001). During the 8 years, the overall fatality rate of inpatients showed an increasing trend (χ2=4.921, P=0.027); the inpatient fatality rate of men showed a gradual increase (χ2=4.278, P=0.039), but the inpatient fatality rate of women was relatively stable (χ2=0.003, P=0.955). There were more males than females who died in hospital (2.09∶〖KG-*2/3〗1); the proportion of males and females in each age group was not completely consistent (χ2=24.141, P=0.004). The top three causes of death in hospitalized patients were tumors (28.77%), circulatory system diseases (24.69%), injury, poisoning and some other consequences of external causes (17.58%).Conclusion The in-hospital mortality rate of males is much higher than that of females. The society should pay attention to the health of males, and strengthen the prevention and intervention of tumors and circulatory system diseases.