青春期血压与血清丙氨酸氨基转移酶的关联性分析

doi:10.3969/j.issn.1006-5253.2021.03.004

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摘要目的探讨青春期血清丙氨酸氨基转移酶（ALT）浓度与血压［收缩压（SBP）、舒张压（DBP）］水平的关系，为青春期人群慢性病区域性防控体系的建立提供一定理论依据。方法 2018年2月至2019年6月，以深圳市9所中学的初一和高一学生为研究对象，按照性别、年龄（10～13岁、14～17岁）和血清ALT四分位数分层后，分析血清ALT水平与血压的关系。结果 7 805例青少年中，平均SBP为（112.87±12.00）mmHg，平均DBP为（71.68±9.61)mmHg。男生组血压高于女生组，SBP为（115.81 vs 109.23）mmHg，DBP为（73.15 vs 69.86）mmHg（P<0.001）；按血清ALT水平的四分位数分层分析显示，随ALT水平等级数值增长血压呈增长趋势（P<0.001）；广义相加模型显示青少年人群血压与血清ALT水平呈相关关系，SBP-ALT（r=0.113～0.279，P<0.001），DBP-ALT（r=0.088～0.208，P<0.001）；二分类logistic回归分析显示，青少年人群的高血压与血清ALT升高（OR=3.411，95%CI：2.215～5.251）及男性（OR=3.684，95%CI：2.594～5.231）有关联。结论青春期血压升高与血清ALT升高存在关联性，当地政府应提高监测中学生血压及ALT同步升高情况的警惕性。

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	赵燕飞
	陈丽桥
	方佳英
	丁赞

关键词 ：血压, 丙氨酸氨基转移酶, 青少年, 关联性

Abstract：Objective To explore the relationships between the concentrations of serum alanine aminotransferase (ALT) and the levels of systolic（SBP）and diastolic blood pressure（DBP）among adolescents. Methods From February 2018 to June 2019, 7 805 students were enrolled in 9 junior and senior high schools in S〖JP2〗henzhen. Stratified analyses were performed according to gender, age (10-13 years old or 14-17 years old) and serum ALT quartiles (≤ 9 U/L, 10-11 U/L, 12-15 U/L, or >15 U/L). Results The SBP of adolescents was (112.87±12.00) mmHg and average DBP was (71.68±9.61) mmHg among the 7 805 adolescents. The blood pressure of the male group was higher than that of the female group, with SBP (115.81 vs 109.23) mmHg and DBP (73.15 vs 69.86) mmHg (P<0.001); stratified analysis by quartile of serum ALT level showed that blood pressure increased with the increase of ALT level (P<0.001); the generalized additive model showed that there was a correlation between blood pressure and serum ALT level in adolescents, SBP-ALT (r=0.113-0.279, P<0.001), DBP-ALT (r=0.088-0.208, P<0.001); the results of binary logistic regression analysis showed that hypertension was associated with elevated serum ALT (OR=3.411, 95%CI: 2.215-5.251) and boys (OR=3.684, 95%CI:2.594-5.231) among adolescents. Conclusion There is a correlation between elevated blood pressure and elevated serum ALT levels in adolescence, and the local government should increase the vigilance to monitor the simultaneous elevation of blood pressure and ALT in middle school students.

Key words： blood pressure alanine aminotransferase adolescent association

收稿日期: 2020-12-08

基金资助:深圳市医疗卫生基础研究项目（2020JD109）；
深圳市宝安区中心医院慢病防治科研项目（BCH2019004）

通讯作者: 丁赞，Email:dingzan_1990@163.com

引用本文:

赵燕飞，陈丽桥，方佳英，丁赞. 青春期血压与血清丙氨酸氨基转移酶的关联性分析[J]. 中国医院统计, 2021, 28(3): 211-214.
Zhao Yanfei, Chen Liqiao, Fang Jiaying, Ding Zan. Relationship between blood pressure and serum alanine aminotransferase among adolescents. journal1, 2021, 28(3): 211-214.

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http://manu58.magtech.com.cn/Jwk_zgyytj/CN/10.3969/j.issn.1006-5253.2021.03.004 或 http://manu58.magtech.com.cn/Jwk_zgyytj/CN/Y2021/V28/I3/211

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