Objective To investigate nurses′ intent to stay during COVID-19 and explore its influencing factors. Methods With the help of the wenjuanxing online survey platform, the general information questionnaire, nurses′ job stressor scale and nurses′ intent to stay questionnaire were used for the survey. Results Totally 519 valid questionnaires were received in this study. The total score of nurses′ intent to stay was (22.12±4.36), which was higher than the results of domestic research in recent 5 years (P<0.05). The independent influencing factors of nurses′ intent to stay were professional choice, working years, whether the department had colleagues to help Hubei, whether to let their children study medicine, problems in nursing profession and work, problems in patient care, and problems in management and interpersonal relationship (P<0.05). Conclusion The perceived intent to stay is above the middle level, which is higher than many domestic researches in recent 5 years. However, nursing managers still need to pay attention to the reasonable needs of nurses, optimize manpower allocation, and further improve the nurses′ intent to stay.