Objective Explored diagnosis related groups of prostatic cancer, and provided references for payment method and hospitalization standard expenses.Methods Screened group nodes of prostatic cancer by multiple linear regression, and established the diagnosis related  groups by CHAID of decision tree. Evaluated model and calculated hospitalization standard expenses and weight of each group.Results Operation methods, comorbiditiesand complcations, agegroups, were group nodes（F=1 334.574，P<0.001，R2=0.711）. Decisiontree model divided into 8 diagnosis related  groups，and calculated hospitalization standard expenses and weights(value at risk is 0.193,CV -varied between 0.01 and 0.07,RIV=0.76).Conclusions Thediagnosis related groups of prostatic cancer are reasonable, and hospitalization standard expenses and weight of each group may provide data support and decision reference for hospitals and health care institutions.