恩度治疗非小细胞肺癌的快速卫生技术评估

doi:10.3969/j.issn.1006-5253.2020.02.017

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摘要

目的利用快速卫生技术评估工具对恩度治疗非小细胞肺癌(nonsmall cell lung cancer, NSCLC)进行有效性、安全性、经济性评估，为临床药物选择提供循证证据。方法通过计算机检索 PubMed、the Cochrane Library、Embase 等英文数据库和中国知网( CNKI) 、万方和CBM等中文数据库，2 名评价者独立提取数据结果。仅纳入恩度治疗NSCLC的系统评价、Meta 分析、卫生技术评估和药物经济学研究，同时采用描述性分析对研究结论进行分类汇总。结果共纳入9篇文献，8篇为系统评价，1篇为药物经济学研究。与标准化疗方案比较，恩度联合化疗方案可提高NSCLC患者的有效率、疾病控制率和临床收益率。安全性研究结果显示，两组方案不良反应发生率的无统计学差异。药物经济学研究显示联合化疗方案可提高NSCLC患者的质量生命调整年，但成本效果不优于标准化疗方案。结论恩度联合化疗方案治疗NSCLC具有良好的有效性和安全性，在我国当前恩度成本效益不佳，但在人均GDP较高地区，恩度可能具有良好的经济性。

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	金情政
	郑彩霞
	王梅

关键词 ：恩度, 非小细胞肺癌, 快速卫生技术评估

Abstract：Objective To evaluate the effectiveness, safety and economy of Endostar in non-small cell lung cancer patients using rapid health technology assessment, and to provide evidence for clinical drug selection．Methods English databases such as PubMed, the Cochrane Library and Embase, and Chinese databases such as CNKI, Wanfang and CBM were searched with computers, and two reviewers extracted the data results independently. Only the systematic evaluation, meta-analysis, health technology assessment and pharmacoeconomic research of Endostar treatment for NSCLC were included, and descriptive analysis was used to classify and summarize the research conclusions. Results Eight systematic reviews and 1 pharmacoeconomic study were included．Compared with the standard chemotherapy, Endostar combined with chemotherapy could improve the efficiency, disease control rate and clinical benefit rate of NSCLC patients. The safety studies showed that there was no significant difference in adverse events between the two groups. Pharmacoeconomics studies have shown that Endostar combined chemotherapy could improve the quality-adjusted life-year of patients with NSCLC, but was unlikely to be considered cost-effective. Conclusion Endostar is an efficacious and safe choice for non-small cell lung cancer treatment, but only in areas with a high per-capita GDP, Endostar may be a cost-effective treatment option.

Key words： Endostar non-small cell lung cancer rapid HTA

收稿日期: 2019-05-20

基金资助:浙江省药学会医院药学专项科研资助项目（2018ZYY52）

通讯作者: 金情政，Email：791915814@qq.com

引用本文:

金情政,郑彩霞,王梅. 恩度治疗非小细胞肺癌的快速卫生技术评估[J]. 中国医院统计, 2020, 27(2): 156-160.
Jin Qingzheng, Zheng Caixia, Yu Wangmei. . Rapid health technology assessment of Endostar in nonsmall cell lung cancer. journal1, 2020, 27(2): 156-160.

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