[1] Yang WY, Lu JM, Weng JP, et al.Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010,362(12):1090-1101. [2] Kira B, Feldman EL. Insulin resistance in the nervous system[J]. Trends Endocrinol Metab, 2012,23(3):133-141. [3] Lu B,Yang ZH,Wang M,et al. High prevalence of diabetic neuropathy in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown[J]. Diabetes Res Clin Pract,2010,88(3) :289-294. [4] 周雁,郭立新,周璐. 老年2型糖尿病患者周围神经病变的影响因素[J].山东大学学报:医学版,2012,22(6):1-4. [5] Lee KO, Nam JS, Ahn CW, et al. Insulin resistance is independently associated with peripheral and autonomic neuropathy in korean type 2 diabetic patients[J]. Acta Diabetol, 2012,49(2):97-106. [6] 姜涛,宋秀霞,张敏. 波动性高血糖对2型糖尿病患者周围神经病变的影响[J].中国慢性病预防与控制,2010,11(1):54-56. [7] Kim B, Mclean L′L,Philip SS,et al. Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons[J]. Endocrinology, 2011,152(10):3638-3647. [8] Toth C, Brussee V, Martinez JA,et al. Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin[J]. Neuro-science, 2009,139(2):429-449. [9] Xu QG, Li XQ,Kotecha SA,et al. Insulin as an in vivo growth factor[J]. Exp Neurol, 2012,188(1):43-51. [10]Hoybergs YM, Meert TF. The effect of low-dose insulin on mechanical sensitivity and allodynia in type 1 diabetes neuropathy[J]. Neurosci Lett, 2010,417(2):149-154. [11]Cusi K, Maezono K, Osman A,et al. Insulin resistance differentially affects the pi 3-kinase-and map kinase-mediated signaling in human muscle[J]. J Clin Invest, 2009,105(3):311-320.