Abstract：Objective To understand the epidemic status of hepatitis B (HBV) in Gaomi, and provide scientific basis for improving the strategy of hepatitis B vaccine. Methods In October 2014, a stratified multi-stage random sampling method was adopted to investigate the prevalence of serum epidemiology in Gaomi among 1~, 5~, 15~ and 30~59 year-old group resident population. Enzyme linked immunosorbent assay (ELISA) was used to detect HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-Hbe. Results A total of 497 people were investigated, the prevalence rate of HBV, HBsAg positive rate, Anti-HBs positive rate and Anti-HBc positive rate were 12.55%, 1.42%, 52.02% and 12.55% respectively. The differences of HBV prevalence rate, HBsAg positive rate, positive rate of Anti-HBs, and positive rate Anti-HBc between men and women had no statistical significance (χ2=0.03,0.41,0.25 and 0.01, P>0.05). Among the age groups: the prevalence rate of HBV among 1~, 5~, 15~ and 30~59 group were 2.14%, 0.99%, 17.53% and 26.28% respectively. The difference was statistically significant (χ2=55.10, P<0.01). The rate for the 5~ year-old group was the lowest, the rate for the 30~59 year-old group was the highest, showing a increasing trend with the age growth. HBsAg positive rate for 1 to 5~year-old group wasn′t detected out, those for 15~, 30~59 age groups were 2.06% and 3.21%, without statistically significant differences (χ2=7.32, P>0.05). The positive rates of Anti-HBs: 1~, 5~, 15~ and 30~59 year-old groups were 67.86%, 55.45%, 54.64%, 33.97% respectively. The difference was statistically significant (χ2=35.16, P<0.01), showing a decreasing trend with the age growth. The positive rates of Anti-HBc for 1~, 5~, 15~and 30~59 were 2.14%, 0.99%, 17.53%, 26.28% respectively. The difference was statistically significant (χ2=55.10, P<0.01), with the 5~ year-old group the lowest, and the rate increased with age. Conclusion Gaomi is still the moderate endemic area of hepatitis B, and the prevalence of HBV in adolescents and adults is higher than that in children. The implementation of the ″neonatal HePB vaccination″ as the main hepatitis B control strategy in Gaomi City has achieved remarkable results.
邱德山, 徐东, 王怡. 高密市2014年人群乙肝血清学调查结果分析[J]. 中国医院统计, 2017, 24(2): 88-91.
Qiu Deshan, Xu Dong, Wang yi. Investigation and analysis of hepatitis B serology of the crowd in Gaomi in 2014. journal1, 2017, 24(2): 88-91.
