Relationship between serum uricemic, blood glucose and coronary heart disease in patients with nonalcoholic fatty liver disease
Wang Xiaohan1, Shen Liang2, Chen Yunqing3, Shen Yueyu3, Gao Chen1, Hou Zhentao1, Han Feng1, Ji Zizhong1
1 Department of Gastroenterology and Hepatology, First Affiliated Hospital of Jiaxing University, Jiaxing 314000, China;
2 Department of Cardiology, First Affiliated Hospital of Jiaxing University, Jiaxing 314000, China;
3 Department of Infectious Diseases, First Affiliated Hospital of Jiaxing University, Jiaxing 314000, China
Objective To analyze the relationship between serum uricemia, blood glucose and coronary heart disease in patients with nonalcoholic fatty liver disease (NAFLD). Methods Two hundred and nineteen NAFLD patients with coronary angiography admitted to our hospital from January 2016 to December 2016 were enrolled. Ultrasound or CT examination was used to diagnose fatty liver. Factors affecting coronary artery disease were analyzed by Logistic multivariate regression. Results Among all NAFLD patients, 62 were nonCHD patients and 157 were NAFLD patients with CHD. In NAFLD patients with coronary heart disease, ALT, AST, GGT, Cr, SUA and GLU increased and HDL decreased compared with NAFLD patients, and the differences were statistically significant. Multivariate Logistic regression analysis showed that increased risk of coronary heart disease was associated with blood glucose (OR=1.426, 95%CI:1.077-1.887) and serum uric acid (OR=1.005,95%CI:1.001-1.009) in males(OR=2.296, 95%CI: 1.153-4.572). Conclusion In patients with NAFLD complicated with coronary heart disease, it is necessary to timely understand the risk factors, control blood glucose level and serum uric acid level, strengthen intervention, and reduce the incidence of coronary heart disease.
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