Objective To explore the risk factors of suicide behavior of bipolar disorder (BPD)patients, and proride prevention measures for it. Methods Totally 540 BPD patients were carried out a follow-up survey,and these patients were divided into the suicide behavior group (194 cases) and the non-suicide behavior group(346 cases)according to suicide behavior. The risk factors of suicide behavior of BPD patients were respectively screened by single factor and multiple factors stepwise Logistic regression methods.Results The rate of suicide behavior in these 540 cases of BPD was 35.93%.The risk factors of suicide behavior of BPD patients included female (OR=1.846),family suicide history (OR=3.117),history of major trauma (OR=4.154),depression degree (OR=5.254),poor interpersonal relationships (OR=2.801) and a sense of worthlessness or guilt(OR=3.615). Conclusion BPD patients have a high rate of suicide behavior, and there are many independent riskf actors affecting suicide behavior. Psychiatrists should pay atteation, and prevention measures should be adopted early, to reducesuicidal tendencies and suicide behavior.