Objective To explore the prognosis and is risk factors of acute cerebral infardt (ACI) patients after the treatment with venous thrombdlysis.Methods Totally 178 ACI patients after treatment of venous thrombolysis were caried out a following-up survey within 3 months.These patients were divided into the good prognosis group(102 cases)and the por progno-sis group(76 cases)according to the evaluation of prognosis. The incidencerate o por prognosis of ACI patients after venous thrmbolysis treatment was descriled, and the risk factors of por prognosis were screened.Results The incidence rate of poor prognosis of ACI patients after enous thrombolyis reatment was 42.70%(76/178).The risk factos of por prognosis included hypertension(OR =6.589),thrombolysis time window(OR=3.162),NIHSS score before thrombolsis(OR=6.058),blod glucse before thrombolysis(OR=3.452)and cerebral hemorhage after thrombolysis(OR =4.039),but improwement of neuro-logical symptoms after 24h of thromblysis(OR=0.135)was the protective factors of poor prognosis. Conclusion ACI patients sill have a high incidence mte of por prognosis after venous thrombolyis. To aim directly at these above high risk factors,ACI patients should be caried out venous thrombolyis in the thrombolysis time window, and prevention measures should be early a-doped, to improve prognosis of ACI patients.