ICD-10 septicemia is classified as pathogenic bacteria. In recent years, more and more attention has been paid to systemic reactions of organisms to microorganisms and their toxins in the study of septicemia, and life-threatening organ dysfunction caused by maladjustment of host response to infection is called sepsis. The diagnosis of sepsis does not require positive blood culture results. Since ICD-10 coding of septicemia A41.9 could not accurately express the severity and disease characteristics of clinical sepsis, the national version of the coding library made a distinction with the expanded code, such as A41.900 septicemia and A41.901 sepsis. Various clinical definitions and terms are easily confused. In order to better understand the clinical terms, the definition and coding of icd-10 sepsis related diseases are summarized. At present, when the country does not use ICD-11 code, the country discusses how to accurately classify related diseases with ICD-10 and can reflect the new progress of clinical research.