Effects of group B streptococcus infection and disorder of vaginal microflora on maternal and infant outcomes in women with premature rupture of term membranes
Objective To investigate the streptococcus B infection in women with premature rupture of term membranes and the effect of vaginal microbiome disorders on maternal and infant outcomes, and to provide basis for clinical treatment and prevention.Methods Eightyfour pregnant women with premature rupture of membranes admitted to our hospital from January 2017 to December 2018 were selected as the research group, and 84 cases of pregnant women without premature rupture of membranes at full term were selected as the control group during the same period. The streptococcus B carriers and vaginal microflora in the lower reproductive tract of the two groups of pregnant women were observed and compared, and their effects on maternal and infant outcomes were summarized.Results The rate of group B streptococcus in the pregnant women in the study group was 19.05%, the proportion of pregnant women′s vaginal PH value > 4.5 was 60.71%, and the incidence rate of vaginal microflora disorder was 84.52%, which were all higher than those of the control group (3.57%, 35.71%, 55.95%), and the difference was statistically significant (χ2=8.924, 12.037, and 18.271, P<0.05). However, there was no statistically significant difference between the two groups in terms of bacterial vaginitis, candida vulvovaginitis and vaginal cleanliness (P>0.05). The infection rate of group B streptococcus positive was 31.25%, the incidence of chorioamnionitis was 31.25%, the incidence of fetal distress was 37.50%, and the incidence of neonatal pneumonia was 31.25%, higher than those of group B streptococcus negative 7.35%, 7.35%, 7.35%, and 4.41%, so there was statistically significant difference (χ2=8.366,11.177, 12.215, 8.333, P<0.05). There was no significant difference in the incidence of puerperal infection rate, chorionic amnionitis, fetal distress and neonatal pneumonia between the pregnant women with microbiome disorder and the normal ones (P>0.05). Conclusion Group B streptococcus bacteria in pregnant women with premature rupture of term membranes had a negative effect on maternal and infant outcomes, while the disorder of vaginal microflora had no significant effect on maternal and infant outcomes. Therefore, clinical attention should be paid to the situation of group B streptococcus bacteria in pregnant women.
余勤俭,张梦思,陈杨萍. 足月胎膜早破孕妇B族链球菌带菌情况及阴道微生物群紊乱对母婴结局的影响[J]. 中国医院统计, 2019, 26(5): 340-342.
Yu Qinjian, Zhang Mengsi, Chen Yangping.. Effects of group B streptococcus infection and disorder of vaginal microflora on maternal and infant outcomes in women with premature rupture of term membranes. journal1, 2019, 26(5): 340-342.
[1]徐桂荣.妊娠晚期孕妇B族溶血性链球菌感染对妊娠结局影响的临床研究[J].实用妇科内分泌杂志(电子版),2016,3(14):87-88.
[2]熊丽丽,田晓予,郭凤仙.妊娠晚期孕妇B族溶血性链球菌感染对妊娠结局影响的临床研究[J].中华医院感染学杂志,2015,25(23):5482-5484.
[3]PETERSEN KB,JOHANSEN HK,ROSTH J S,et al.Increasing prevalence of group B streptococcal infection among pregnant women[J].Dan Med J,2014,61(9):A4908.
[4]彭兰,柴利强,陈大立,等.孕妇孕晚期GBS定植及新生儿早发型GBS感染趋势[J].中国妇幼健康研究,2016,27(1):26-28.
[5]麦秀琴.对B族溶血性链球菌带菌者早期干预与母婴感染的探讨[J].临床护理杂志,2016,15(1):5-7.
[6]BRIGTSEN AK,DEDI L,MELBY KK,et al.Comparison of PCR and serotyping of group B Streptococcus in pregnant women:The Oslo GBSstudy[J].J Microbiol Methods,2015,108:31-35.
[7]SCHOLL J, NASIOUDIS D,BOESTER A,et al.Group B Streptococcus alters properties of vaginal epithelial cells in pregnant women[J].Am J Obstet Gynecol,2016,214(3):383.e1-383.
[8]张莹,孙晖,王英,等.抗感染干预对孕妇生殖道B族链球菌感染胎膜早破的影响[J].中华医院感染学杂志,2017,27(1):179-181.
[9]谭玉杰,海巨珺,王颢.妊娠晚期孕妇生殖道B族链球菌感染对母婴预后的影响[J].中华医院感染学杂志,2015,25(18):4279-4281. [10]郭华峰,杨筱青,杨俊娟.妊娠晚期孕妇生殖道B族溶血性链球菌感染及临床结局研究[J].中国妇幼保健,2014,29(30):4897-4898.