Objective To explore the risk factors of acute kidney injury (AKI) in critically ill patients.Methods In a prospective nested casecontrol study, critically ill patients who were admitted to the ICU ward of a tertiary hospital were followed up as a cohort. They were divided into the case group and the control group according to the acute kidney injury, and the clinical basic characteristics of both groups were compared. Multivariate logistic regression was used to analyze the influencing factors of AKI in critically ill patients.Results Totally 426 critically ill patients meeting the inclusion criteria entered the cohort, with 112 patients in the case group and 314 patients in the control group. There were significant differences between both groups in gender, age, APACHE II score, number of extrarenal organ failure, severe infection, CKD, hypertension, diabetes, surgery, arterial oxygen partial pressure, lactic acid, blood calcium, serum creatinine, platelets, blood urea nitrogen, serum creatinine, aspartate aminotransferase, and brain natriuretic peptide (P<0.05). Multivariate logistic regression analysis showed that the risk factors for AKI of critically ill patients included age, APACHE II score, and extrarenal organ failure. number, severe infection, CKD, surgery, serum creatinine, and brain natriuretic peptide, with the probability lower than 0.001.Conclusion Old age, high APACHE II score, extrarenal organ failure, severe infection, CKD, surgery, elevated serum creatinine, and elevated brain natriuretic peptide were major risk factors for AKI of critically ill patients, and the abovementioned abnormal indicators suggest increased risk of AKI in patients, so attention should be paid in the c
李秀元,高金霞,张增雷,吕恒娟,宋秋颖,李强,叶虹婷. 危重症患者急性肾损伤发生危险因素的巢式病例对照研究[J]. 中国医院统计, 2019, 26(4): 249-252.
Li Xiuyuan, Gao Jinxia, Zhang Zenglei, Lü Hengjuan, Song Qiuying, Li Qiang, Ye Hongting. Nested casecontrol study on risk factors of acute kidney injury of critically ill patients. journal1, 2019, 26(4): 249-252.
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