Risk factors investigation analysis on rehaemorrhagia about intracranial rupture aneurysm patients before operation
Shang Qinfen1, Yang Ling2, Huang Danhong3
1 Neurosurgical Department of Enze Hospital in Enze Medical Group in Taizhou, 318050, China; 2 Taizhou Central Hospital; 3 Luqiao Hospital of Enze Medical Group
Abstract:Objective To explore the correlated risk factors of rehaemorrhagia about intracranial rupture aneurysm patients before operation, and provide basis for preventing rehaemorrhagia. Methods With retrospective case-control study method, 465 cases of definite intracranial rupture aneurysm patients before operation were investigated by questionnaire. These cases were divided into rehaemorrhagia group (n=113) and non-rehaemorrhagia group (n=352), and the risk factors of rehaemorrhagia were screened by single factor and multiple factors methods. Results The incidence rate of intracranial rupture aneurysm patients before operation reached up to 24.3% (113/465). Multiple factors logistic regression analysis results showed that these factors such as history of hypertension (OR=4.092), complication with cerebral angiospasm (OR=1.893), epilepsy (OR=3.013), tumor diameter (OR=2.787), and moving too early or out-of bed activity of prematurity (OR=4.179) were all the risk factors of rehaemorrhagia about intracranial rupture aneurysm patients before operation. Conclusion There is still a little high incidence rate of rehaemorrhagia about intracranial rupture aneurysm patients before operation, and it affects the prognosis of these patients. There are many risk factors affecting the incidence rate of rehaemorrhagia, so we should adopt intervention measures to aim directly at these high risk factors.
[1] 徐美娣,贾颖,蒋燕.脑动脉瘤破裂后再出血的高危因素分析及护理对策[J].实用临床医药杂志,2012,16(22):163-165. [2] ROOS YB, HAAN RJD, BEENEN LF, et al. Complications and outcome in patients with aneurysmal subarachnoid haemorrhage: a prospective hospital based cohort study in The Netherlands[J]. J Neurol Neurosurg Psychiatry, 2000,68(3):337-341. [3] 李京生,赵继宗,齐巍,等.动脉瘤病人住院期间再出血死亡相关因素分析[J].中华神经外科杂志,2009,17(2):81-82. [4] KOOIJMAN E, NIJBOER H, VELTHOVEN CT, et al. The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies[J]. J Neuroinflammation, 2014,11(3):1-2. [5] 魏秀霞,王峰,赵荣丽,等.颅内动脉瘤破裂出血危险因素的护理干预影响[J].河北医药,2012,34(2):301-302. [6] 龙先喻,黄晓松,袁波,等.颅内动脉瘤性蛛网膜下腔出血血管痉挛治疗的临床探讨[J].临床神经外科杂志,2012,9(2):76-77. [7] MUELLER-KRONAST N, JAHROMI BS. Endovascular treatment of ruptured aneurysms and vasospasm[J]. Curr Treat Options Neurol, 2007,9(2):146-157. [8] KIM C, LEE JL, CHOI YH, et al. Phase I dose-finding study of sorafenib in combination with capecitabine and cisplatin as a first-line treatment in patients with advanced gastric cancer[J]. Investig N Drugs, 2012,30(1):306-315. [9] MACHIEL PLEIZIER C, ALGRA A, VELTHUIS BK, et al. Relation between sieze of aneurysms and risk of rebleeding in patients with subarachnoid heaemorrage[J]. Acta Neurochir (Wien), 2006,148(12):1277-1279. [10]韩凤伟,杨玉香,呼铁民,等.循证护理在预防颅内动脉瘤破裂再出血中的应用[J].中国医药导报,2011,8(6):84-85.