Abstract：Objective To observe the adverse reaction types of ciprofloxacin injection and to explore the influencing factors on the incidence of adverse reactions. Methods The cases of ciprofloxacin injection were studied in our hospital from January 2013 to December 2015, and retrospective analysis was used to record the gender, age and other clinical data of the patients. Characteristics and incidence rate of adverse reaction of ciprofloxacin injection were statistically studied, and non-conditional logistic regression analysis was used to explore the possible factors influencing the adverse reaction of ciprofloxacin injection. Results A total of 1 689 cases were included in the study, and among them, 53 cases of adverse reactions were caused by ciprofloxacin, with the incidence rate 3.14%. The adverse reactions mainly occurred in the digestive system, nervous system and skin appendages, accounting for 90.57% of all the adverse reactions. Chi square test single factor analysis showed that age, history of allergies, the combination of medication, course of treatment and dosage of the drug may be the risk factors for adverse reaction of ciprofloxacin injection, and the results of non conditional logistic regression analysis showed that age, history of allergy, combined medication, treatment duration and dosage were independent risk factors for adverse reaction of ciprofloxacin (P< 0.05). Conclusion The incidence rate of adverse reaction of ciprofloxacin injection is low, but the adverse reaction can occur in multiple organ systems, and the incidence is high in digestive system, nervous system, skin and accessory system. Non conditional logistic regression showed that age, history of allergy, combined use of other antimicrobial agents, and drug administration were all independent risk factors for adverse reaction of ciprofloxacin injection. Clinical application of ciprofloxacin injection needs a detailed understanding of the patient′s history and related information, and patients with high-risk should pay close attention to the possible adverse reactions.
李建娣, 沈志华. 环丙沙星注射液不良反应影响因素的非条件logistic回归分析[J]. 中国医院统计, 2016, 23(6): 412-414.
Li Jiandi, Shen Zhihua. Non-conditional logistic regression analysis on the influencing factors of the adverse reaction of ciprofloxacin injection. journal1, 2016, 23(6): 412-414.
