Abstract：Objective To systematically evaluate the efficacy of wuziyanzong and levocarnitine in the treatment of male infertility. Methods Based on the principles and methods of Cochrane systematic reviews, we searched PubMed, Embase, the Cochrane Library, EBSCO, CNKI, VIP, CBM and Wanfang databases from inception to July 2017 for randomized controlled clinical trials addressing the treatment of male infertility with wuziyanzong. According to the inclusion and exclusion criteria and retrieval strategies, we extracted the data, evaluated the quality of the included literature, and conducted meta-analysis using the RevMan 5.3 software. Results Four trials involving 324 patients were included. The results of meta-analysis showed that effectiveness rate(RR=1.25,95%CI:0.99~1.58,P=0.06), confirmed pregnancy rate(RR=1.76,95%CI:0.81~3.82,P=0.15), △semen volume(MD=-0.04,95%CI:-0.41~0.34,P=0.85), △sperm density(SMD=0.65,95%CI:-0.12~1.43,P=0.10), △grade A sperm rate(MD=1.89,95%CI:-10.41~14.20,P=0.76)and △grade A+B sperm rate(MD=3.42,95%CI:-5.00~11.84,P=0.43) of wuziyanzong group were not inferior to those of levocarnitine group, but △sperm motility of wuziyanzong group was inferior to that of levocarnitine group (MD=-12.42,95%CI:-22.06~ -2.78,P=0.01). Conclusion According to this evaluation system, wuziyanzong treatment of male infertility has some curative effect, but because of some limitations, it still needs large-scale randomized controlled clinical trial for verification according to dialectics of traditional Chinese medicine.
何芳香, 毛雄伟, 吴慧. 五子衍宗方与左卡尼汀治疗男性不育症的Meta分析[J]. 中国医院统计, 2018, 25(4): 245-249.
He Fangxiang, Mao Xiongwei, Wu Hui. Meta-analysis of wuziyanzong and levocarnitine for male infertility. journal1, 2018, 25(4): 245-249.
