Abstract:Objective To explore the risk factors of intraoperative floppy-iris syndrome (IFIS), so as to provide evidence for its clinical prevention and treatment. Methods Totally 482 patients (554 eyes) with age related cataract treated in the hospital were analyzed retrospectively, in which 53 patients (56 eyes) occurred IFIS. The clinical data of all the patients were analyzed, and the risk factors of IFIS were established by single factor analysis and logistic regression analysis. Results Single factor analysis results showed that age, sex, body mass index, alpha 1 receptor antagonist medication history (including tamsulosin, dorsey azole oxazine, terazosin and alfuzosin), benzodiazepines drug medication history, and antipsychotic drug history were likely to affect the incidence of IFIS in cataract ultrasonic emulsification surgery (P<0.05), while visual acuity, intraocular pressure, duration, cataract nucleus hardness grading, complications and surgical type had no significant difference (P>0.05). Logistic regression analysis results showed that 70 years old and above (OR=2.079), alpha 1 receptor antagonist medication history, benzodiazepines drug medication history and antipsychotic drug history were risk factors of IFIS (P<0.05, OR>1.0). Conclusion This study systematically summarizs the influence factors and risk factors of IFIS of senile cataract surgery, and has a certain guiding significance for the clinical prevention and treatment of IFIS.
温积权,洪明胜,陈益丹,曹永葆,徐洁慧. 老年性白内障术中虹膜松弛综合征的危险因素分析[J]. 中国医院统计, 2018, 25(3): 176-178.
Wen Jiquan, Hong Mingsheng, Chen Yidan, Cao Yongbao, Xu Jiehui. Risk factor analysis of IFIS in age related cataract surgery. journal1, 2018, 25(3): 176-178.
[1] GRZYDOWSKI A, KRZYZANOWSKBERKOWSKA P. Intraoperative floppy iris syndrome (IFIS): what complication rates can we expect[J]. Graefes Arch Clin Exp Ophthalmol, 2014,252(5):845-846. [2] GOYAL S, DALELA D, GOYAL NK, et al. Intraoperative floppy iris syndrome in Indian population: A prospective study on incidence, risk factors, and impact on operative performance[J]. Indian J Ophthalmol, 2014,62(8):870-875. [3] 孙冰,孙思勤,温跃春,等. α-1受体拮抗剂患者瞳孔直径与Phaco术中虹膜松弛综合征的关系[J].眼科新进展,2014,34(2):172-174. [4] ZAMAN F, BACH C, JUNAID I, et al. The Floppy Iris Syndrome -What Urologists and Ophthalmologists Need to Know[J]. Curr Urol, 2012,6(1):1-7. [5] GUPTA A, SRINIVASAN R. Floppy iris syndrome with oral imipramine: A case series[J]. Indian J Ophthalmol, 2012,60(2):136-138. [6] DOSS EL, POTTER MB, Chang DF. Awareness of intraoperative floppy-iris syndrome among primary care physicians [J]. J Cataract Refract Surg, 2014,40(4):679-680. [7] 辛美颜,崔巍. 白内障超声乳化术中虹膜松弛综合征的研究进展[J].国际眼科杂志,2016,16(6):1063-1066. [8] 俞捷心. 中国医院内的白内障超声乳化术术中虹膜松弛综合征的发生观察[D].杭州:浙江大学,2014. [9] ISSA SA, HADID OH, BAYLIS O, et al. Alpha antagonists and intraoperative floppy iris syndrome: A spectrum[J]. Clin Ophthalmol, 2008,2(4):735-741. [10]王素芹,田华,孙晓凤,等.二分类logistic 回归在冠心病危险因素研究中的应用[J].中国医院统计,2014,21(2):81-84. [11]刘金梅,刘品壮,陈亦新,等.某肿瘤医院2007—2012年就诊肺癌病人地区分布情况调查[J].中国医院统计,2015,22(6):474-477. [12]崔红美,吴桂莲,田青青,等.心血管内科住院患者医院感染因素统计分析[J].中国医院统计,2015,22(2):136-137. [13]CHANG DF, CAMPBELL JR. Introperative floppy iris syndrome associated with tamsulosin[J]. J Cataract Refract Surg, 2005,31(4):664-673. [14]胡丹,赵刚平,朱敏,等. 白内障超声乳化吸出术中虹膜松弛综合征的危险因素[J].广西医学,2016,38(7):962-965. [15]刘姣,吴林彬,周家承,等. 白内障术中虹膜松弛综合症的临床分析[J].国际眼科杂志,2011,11(6):1055-1057. [16]容蓉,徐婷婷,邵毅. 虹膜松弛综合征的临床研究[J].眼科新进展,2017,37(2):189-191. [17]DEEB TZ, MAGUIRE J, MOSS SJ. Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures[J]. Epilepsia, 2012,53(9):79-88.