The relationship between TSHR gene polymorphism and the prognosis of Graves′ disease in different clinical subtypes
Zhang Ying1, Liu Lin1,2, Shen Min3, Li Rujiang4, Lu Hongwen2
1 The Graduate Department of Weifang Medical University, Weifang 261053,China; 2 Department of Endocrinology, Weifang People′s Hospital; 3 Department of Genetics, Shanghai-Ministry of Science and Technology (MOST) Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Xinhua Hospital; 4 College of Basic Medical Sciences,Weifang Medical University.
Abstract：Objective To investigate the relationship between thyroid stimulating hormone receptor (TSHR) gene polymorphism and the prognosis of Graves′ disease (GD) after antithyroid drugs(ATD)treatment in Weifang Han Chinese population of Shandong province. Methods A total of 1 961 patients diagnosed GD who were referred to the Endocrinology Clinic and 533 controls were included in to study from January 2010 to January 2015. By case-control study, the SNP was genotyped by Taqman probe technique on ABI QuantStudioTM 5 real-time PCR system respectively. SPSS 24.0 was used to make statistical analysis. Results According to the study, the SNP site rs179247-A of the TSHR gene intron 1 region was demostrated significantly correlated with GD(PAllelic＜0.001,OR=1.64,95% CI=1.42～1.89). Analysis of model of inheritance suggested that the dominant model should be preferred for rs179247(PDominant＜0.001). However, there was no association between the SNP site rs179247 and different clinical subtypes of GD after antithyroid drugs treatment for at least 24 months(PGenotypic=0.553). Conclusion Our findings demonstrated that the SNP site rs179247 of the TSHR gene intron 1 region was associated with GD, rs179247-A was an independent pathogenic site.However,there was no association between the SNP site rs179247 and different clinical subtypes of GD.
张颖,柳林,沈珉,李如江,卢洪文. TSHR基因多态性与不同临床亚型的Graves′病治疗预后的关系[J]. 中国医院统计, 2018, 25(3): 161-164.
Zhang Ying, Liu Lin, Shen Min, Li Rujiang, Lu Hongwen. The relationship between TSHR gene polymorphism and the prognosis of Graves′ disease in different clinical subtypes. journal1, 2018, 25(3): 161-164.
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