Abstract：Objective To explore the correlated risk factors of prognosis of hypoxic ischemic encephalopathy (HIE) pediatric patients in intensive care unit (ICU), and to provide basis for early improving prognosis of HIE. Methods Totally 186 cases diagnosed with HIE were divided into poor prognosis group (56 cases) and good prognosis group (130 cases) according to the prognosis of HIE. Correlated factors of HIE prognosis were investigated with questionnaires. Then, single and multiple factors Logistic regression methods were used to screen the risk factors of HIE prognosis. Results Poor prognosis rate of HIE was 30.1% (56/186). Multiple factors analysis result showed that these factors of CT grading (OR=2.081), 5 minute Apgar score (OR=3.924), coma (OR=4.059), convulsion (OR=2.570), central respiratory failure (OR=2.354) and multiple organ injury (OR=5.824) were the risk factors of HIE prognosis, while early treatment intervention (OR=5.824) was the protective factor of HIE prognosis. Conclusion These factors such as high grading of CT, low score 5 minute Apgar, severe symptoms (coma, convulsion and central respiratory failure), multiple organ injury and without early treatment intervention were the independent risk factors of poor good prognosis of HIE. So we should adopt necessary intervention measures to aim directly at these independent risk factors.
