Abstract：Objective To evaluate the efficacy and safety of lornoxicam and phloroglucinol treating acute abdominal pain in patients with gallstone. Methods The randomized controlled studies (RCTs) of lornoxicam and phloroglucinol treating acute abdominal pain in patients with gallstone were conducted. Two reviewers independently screened the literatures, extracted data and evaluated the quality of studies. Meta analysis was performed by Revman 5.3 software. Results Compared with the phloroglucinol group (the control group), incidence of adverse drug reactions in the lornoxicam and phloroglucinol group (the combined group) had no significant difference (RR=0.82,95%CI:0.49~1.39, P=0.47). Pain relief time (MD=-28.77,95%CI:-30.39~-27.15, P<0.001), 1H-VAS (MD=-1.88,95%CI:-2.05~ -1.71, P<0.001) and pain recurrence rate (RR=0.46,95%CI:0.28~0.62, P<0.001) in the combined group were significantly better than those in the control group. Conclusion From this systematic review, lornoxicam and phloroglucinol treating acute abdominal pain in patients with gallstone is safe and effective. But there are some limitations in this study, which still need to be validated with traditional drug control, good design, multi centers and large scale clinical randomized controlled study.
姚莉莉, 孙成范, 俞建华, 徐锦龙. 氯诺昔康联合间苯三酚治疗胆囊结石致急性腹痛的Meta分析[J]. 中国医院统计, 2018, 25(1): 1-4.
Yao Lili, Sun Chengfan, Yu Jianhua, Xu Jinlong. Meta analysis on lornoxicam and phloroglucinol treating acute abdominal pain in patients with gallstone. journal1, 2018, 25(1): 1-4.
