Abstract：Objective To investigate the correlation between serum vitamin D3 level and disease severity and disease control in children with asthmatic. Methods 144 cases of children with asthma were divided into mild intermittent group (n=35 cases), mild group (n=36 cases), moderate group (n=48 cases) and severe group (n=25 cases) according to the degree of the disease, and 50 cases of healthy children were selected as control group. Serum 25-(OH)D3 level was detected in control children and asthma children and the childhood asthma control test (C-ACT) was used for evaluation of children with asthma control after 4 weeks treatment. All asthma children were divided into not controlled group, partly controlled group and completely controlled group according to the C-ACT, and serum 25-(OH)D3 levels were compared between groups. Results There were statistically significant differences in serum 25-(OH)D3 levels among the control group, mild intermittent group, mild group, moderate group, and severe group (P<0.05), and from control group to severe group serum, serum 25-(OH)D3 levels gradually decreased (P<0.05). There were statistically significant differences in serum 25-(OH)D3 levels among not controlled group, partly controlled group and completely controlled group (P<0.05), and from completely controlled group to not controlled group, serum 25-(OH)D3 levels gradually decreased (P<0.05). Spearman correlation analysis showed that serum 25-(OH)D3 level was negatively correlated with disease severity (rs=-0.489, P<0.05), and serum 25-(OH)D3 level was also negatively correlated with C-ACT score (rs=-0.470, P<0.05). Multivariable logistic regression analysis showed that risk ratio of asthma children with severity and C-ACT score <19 points of value increased gradually when the serum 25-(OH)D3 level decreased. Conclusion Serum 25-(OH)D3 level is closely related to asthmatic severity and disease control, and early detection of serum vitamin D level has a certain significance in evaluation asthmatic severity and recent prognosis in children with asthma.
朱碧君，章成伟. 血清维生素D水平与哮喘患儿病情严重程度及病情控制的相关性分析[J]. 中国医院统计, 2015, 22(4): 270-273.
Zhu Bijun, Zhang Chengwei. Correlation between serum vitamin D level and disease severity and disease control in children with asthmatic. journal1, 2015, 22(4): 270-273.
[1] 陈建平,赵婉莹,何念海.413例儿童哮喘危险因素Logistic回归分析[J].第三军医大学学报,2011,23(17):1862-1864. [2] Khoo AL,Joosten I,Michels M,et al. 1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells[J]. Immunology, 2011,134(4):459-468. [3] 任芳萍,刘大鹏,杨军兰,等.成人支气管哮喘患者血清25-羟维生素D3水平及其与肺功能的关系[J].中华哮喘杂志,2013,7(4):16-19. [4] 中华医学会儿科分会呼吸组. 儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-750. [5] Liu AH,Zeiger R,Sorkness C,et al.Development and crosssectional validation of the Childhood Asthma Control Test[J]. J Allergy Clin Immunol, 2007,119(4):817-823. [6] 李博,刘恩梅,任洛. 儿童哮喘控制测试与肺功能相关性研究[J].中国实用儿科杂志,2012,18(4):292-295. [7] Holick MF. Vitamin D:evolutionary,physiological and health perspectives[J]. Curr Drug Targets, 2011,12(1):4-18. [8] Alyasin S,Mmnen T,Koshers,et al. TheRelationship between 8et'llm 25 hydmxy vitamin D levels and asthma in children[J]. Allergy Asthma lmmunol Res,2011,3(4):251-255. [9] Rorie A,Goldner WS,Lyden E, et al. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study[J]. Ann Allergy Asthma Immunol,2014,112(4) :376-382. [10]Searing DA,Zhang Y,Murphy JR,et a1.Decreased sel′nm vitamin D levels in children with asthma are asseciated with increaed cortieosteroid use[J]. Allergy Clin Immunol, 2010,125(5):995-1000. [11]Brehm JM, Celedón JC, Soto-Quiros ME, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica[J]. Am J Respir Crit Care Med,2009,179( 9):765-771. [12]侯萍,单丽沈,蔡栩栩,等. 哮喘儿童呼出气一氧化氮与肺功能及哮喘控制测试相关性研究[J].中国实用儿科杂志,2014,32(9):708-712. [13]Lang CL, Wang MH, Chiang CK,et al. Vitamin D and the Immune System from the Nephrologist′s Viewpoint[J]. ISRN Endocrinol,2014,76(11):1231-1239. [14]Di Rosa M,Malaguarnera M,Nicoletti F,et al. Vitamin D3: ahelpful immuno-modulator[J]. Immunology, 2011,134(2):123-139. [15]Halwani R,Al-Muhsen S,Hamid Q. Thelper 17 cells in airway diseases: from laboratory bench to bedside. Thelper 17 cells in airway diseases: from laboratory bench to bedside[J]. Chest, 2013,143(2):494-501. [16]Bossé Y,Maghni K,Hudson TJ. 1α, 25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes[J]. Physiol Genomics,2007,29(2):161-168. [17]Taher YA,van Esch BC,Hofman GA,et al. 1, 25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-beta[J]. J Immunol, 2008,180(8):5211-5221. [18]Khoo AL,Joosten I,Michels M,et al. 1, 25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells[J]. Immunology, 2011,134(4):459-468. [19]Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity[J]. J Mol Med (Berl), 2010,88(5):441-450.
