Abstract：Objective To explore the diagnostic effect of early screening sepsis with procalcitonin (PCT) and C-reactive protein (CRP). Methods Fifty-four patients with sepsis and forty-five healthy patients were respectively collected as the case group and the control group. The indexes of PCT, CRP, WBC and APACHEⅡ score were compared between the two groups. And the sensitivity, specificity, positive predictive value, negative predictive value and accuracy were respectively calculated with PCT, CRP, and PCT in combination with CRP methods. Then, the risk factors of sepsis were analyzed with multiple Logistic Regression method. Results The levels of PCT, CRP, WBC and APACHE Ⅱ scores in the sepsis group were much higher than those in the control group (P<0.01). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of early screening sepsis with PCT in combination with CRP were respectively 92.6%, 84.4%, 87.7%, 90.5%, 88.9%. Multiple Logistic Regression analysis results showed that PCT, CRP, WBC and APACHEⅡ scores were the independent risk factors of the incidence of sepsis. Conclusion These early sepsis patients have a high level of PCT and CRP, and there is high level of sensitivity, specificity and accuracy through early diagnosis.
龚建玲. 血清降钙素原、C反应蛋白早期筛查诊断脓毒血症效果研究[J]. 中国医院统计, 2015, 22(2): 108-110.
Gong Jianling. Effect study on early screening sepsis with procalcitonin and C-reactive protein. journal1, 2015, 22(2): 108-110.
[1] Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012[J]. Crit Care Med, 2013,41(2):580-637. [2] 孙萍,王东强,刘伟,等.脓毒症患者白细胞计数及血清降钙素原和C-反应蛋白的动态变化[J].中华危重病急救医学, 2014, 26(7): 516-518. [3] Levy MM, Fink MP, Marshall JC, et a1. 200l SCCM／ESICM／ACCP／ATS／SIS international sepsis definitions conference[J]. Crit Care Med, 2003,31(29):1250-1256. [4] 张敏,冯志顺,哲彤,等.血清降钙素原和悦反应蛋白检测在脓毒症早期诊断中的意义[J].广东医学,2011,32(17):2260-2262. [5] 徐林发,汪素珍,王柏省.应用ROC曲线求解最佳切点的方法介绍[J].中国卫生统计,2011,28(6):701-705. [6] 朱刚,刘宝.血清C反应蛋白、降钙素原水平对脓毒症的诊断价值[J].蚌埠医学院学报,2011,36(12):1336-1338. [7] 李真玉,刘毅,柴艳芬.血清降钙素原、C反应蛋白、乳酸、细胞因及危重疾病评分对脓毒症预后分析[J].临床荟萃,2011,26(16):1381-1387. [8] 李娜,余国宝,刘毅,等.血清降钙素原与C-反应蛋白联合检测在急诊脓毒症诊断中的价值分析[J].上海医药,2014,35(13):43-46. [9] 李丽娟,陈炜,古旭云,等.血浆PCT 和CRP 水平的动态变化对脓毒症严重程度的评估及其相关性研究[J].中国实验诊断学,2013,17(6):1010-1013. [10]欧回.血清降钙素原与C-反应蛋白在急诊重症监护室脓毒症诊疗中的应用价值[J].中国实用医刊,2014,41(11):118-119. [11]Jongwutiwes U, Suitharak K, Tiengrim S, et al. Serum procalcitonin in diagnosis of bacteremia[J]. J Med Assoc Thai, 2009,92 (2):79-87. [12]王岚, 刘新, 郭秀军. 血清降钙素原与超敏C 反应蛋白联合检测在脓毒症诊断中的意义[J].沈阳医学院学报,2014,16(1):13-17
