Abstract：Objective To explore clinical curative effect of Butylphthalide combined with Edaravone treating acute cerebral infarction patients. Methods Eighty patients with acute cerebral infarction were randomly divided into control group (40 cases) and combination group (40 cases). The control group was given Edaravone and conventional treatment, while the combination group was given Butylphthalide soft capsule on the basis of the control group. The indexes of inflammatory reaction, NIHSS score, Barthel score, total effective rate and adverse effect were compared between the groups. Results After 30 days treatment, the levels of CRP and IL-4 in the combination group were much lower than those in the control group (P＜0.01). NIHSS score and Barthel score in the combination group were much higher than those in the control group (P＜0.01). The total effective rate in the combination group was 95.6%, much higher than that in the control group (80.0%, P＜0.05). There was no statistical significance about adverse effect rate between the two groups. Conclusion Treating acute cerebral infarction patients with Butylphthalide combined with Edaravone could cut down inflammatory reaction, improve nerve function and activities of daily living, raise total effective rate, and lower adverse effect. So it deserves to spread in clinic.
[1] 吴娟,陈永.丁苯酞对急性脑梗死患者临床疗效及血液流变学的影响[J].重庆医学,2012,41(33):3488-3489. [2] 周艳,孙宏侠,张明明,等.丁苯酞辅治老年急性脑梗死的疗效[J].中国老年学杂志,2013,33(12):2895-2897. [3] 骆杭丽.丁苯酞软胶囊治疗急性脑梗死患者的临床效果及安全性[J].中国医药,2014,9(2):188-190. [4] 全国第四届脑血管病学术会议. 脑卒中病人神经功能缺损程度评分标准及临床疗效评定标准[J].中华神经科杂志,1996,29(6):381-383. [5] Liu M, Wu B, Wang WZ, et a1. Stroke in China:epidemiology, prevention, and management strategies[J]. Lancet Neural, 2007,6(5):456-464. [6] 蒙冰,任丁,周凤坤.丁苯酞软胶囊治疗急性脑梗死—40例疗效观察[J].血栓与止血学,2014,20(4):17-19. [7] Zhao Q, Zhang C, Wang XL, et al. (S)-ZJM-289, a nitric-oxide-releasing derivative of 3-n-butylphthalide, protects 89 against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death[J]. Neurochem Int, 2012,60(2):134-144. [8] Nakamura T, Kuroda Y, Yamashit S, et al. Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage[J]. Stoke, 2008,39(2):463-469. [9] Wang X, Li Y, Zhao Q, et al. Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents[J]. Org Biomol Chem, 2011,9(16):5670-5681. [10]奚继明,张江涛,杜海松.丁苯酞联合依达拉奉治疗急性脑梗死临床观察[J].中国医药导报,2011,8(11):73-52.
