Abstract：Objective To explore etiology and correlated risk factors of infection of peripherally inserted central catheter (PICC), in order to provide basis for early preventing PICC infection. Methods With retrospective case-control study method, 68 cases of definite PICC patients were collected as case group, and 136 cases of PICC without infection as control group. All of these study objects in these two groups were investigated with questionnaire, and these factors of PICC infection were screened by single factor and multiple factors Logistic Regression methods. Results There were 68 cases (1.64%) of PICC infection in 4 146 cases of PICC. Pathogens of PICC infection were mainly in Staphylococcus aureus (32 cases, 34.0%), Staphylococcus epidermidis (27 cases, 28.7%) and Candida albicans (19 cases, 20.2%). Multiple factors analysis result showed that the independent risk factors of PICC infection included in combined underlying disease (OR=1.840), Low immune function (OR=2.450), paracentesis times above 2 times (OR=1.958), paracentesis time above 30 minutes (OR=4.035), double channel catheter (OR=3.031) and nursing procedure experience less 50 times (OR=4.473). Conclusion These measures, such as preventing and treating underlying diseases, raising organism immunity, strengthening standardization management of catheter and increasing practical experience of nursing staff, could effectively prevent the incidence of PICC infection.
[1] 穆玉霞,李萍,高俊焕,等.经外周静脉穿刺置入中心静脉导管相关性血流感染的原因分析与对策[J].白求恩军医学院学报,2012,10(4):351-352. [2] 杨益群,乔美珍,赵鑫,等.干预组合预防经外周静脉置入中心静脉导管相关血流感染的效果[J].中华医院感染学杂志,2013,23(17):4132-4136. [3] THILTON D. Central venuos access device infections in the critical care unit[J].Crit Care Nurs Q, 2006,29(2):117-122. [4] SABOJEE H, STEENHOFF A .The health professional′s role in preventing nosocomial infections[J]. Post grad Med J, 2001, 77(903):16-19. [5] 中华医学会重症医学分会. 血管内导管相关感染的预防与治疗指南(2007)[J].中国实用外科杂志,2008,28(6):413-421. [6] 赵霞,段富交,张小琴.肿瘤患者经外周静脉置入中心静脉导管发生导管相关感染危险因素分析[J].中华实用诊断与治疗杂志,2015,29(8):809-811. [7] 陈敏,陈锐,刘丹,等.老年肿瘤患者经外周静脉置入中心静脉导管相关性感染危险因素分析[J].中华医院感染学杂志,2013,23(23):5682-5684. [8] 林群,吴达娟,胡桂芳,等.血液肿瘤患者经外周静脉置入中心静脉导管相关性感染的危险因素与预防措施[J].中华医院感染学杂志,2015,25(17):3982-3984. [9] DABROWSKI A, KWASNIEWSKI W, SKOCZYLAS T, et al. Incidence of human papilloma virus in esophageal squamous cell carcinoma in patients from the Lublin region[J]. World J Gastroenterol, 2012,18(40):5739-5744. [10]黄朝梅,邵巧仪,何力,等.新生儿经外周静脉置入中心静脉导管致导管相关性感染的危险因素成组病例对照研究[J].中国实用乡村医生杂志,2014,21(13):17-20. [11]姜敏,张帆,李红.经外周静脉置入中心静脉导管与超声引导下置管对置管感染影响的临床研究[J].中华医院感染学杂志,2015,25(9):2023-2027. [12]王国权,范静,翟红岩,等.经外周静脉置入中心静脉导管的感染分析与预防[J].中华医院感染学杂志,2010,20(8):1076-1078. [13]郑芝蕾,肖秀漫,陈琼,等.新生儿外周静脉置入中心静脉导管相关性感染的影响因素分析[J].中华医院感染学杂志,2015,25(20):4757-4763. [14]刘敏.经外周静脉穿刺置人中心静脉导管感染的预防及护理进展[J].山西医药杂,2011,40(3):258-260. [15]AHO M, IRSHAD A, ACKERMAN SJ, et al. Correlation of sonographic features of invasive ducatal mammary carcinoma with age, tumor grade, and hormone-receptor status[J].J Clin Ultrasound, 2013,41(1):10-17.
