Objective We analyzed the main composition and changes of tuberculosis hospitalization expenses in hospitals of a municipality in Guangxi from 2013 to 2017, which can be taken as the reference for formulating policy to reduce the economic burden of tuberculosis patients and improve medicine resource allocation.Methods To analyze the main components of hospitalization expenses. The degree of structure variation was used to evaluate hospitalization expenses.Results(1) The median of hospital days per capita showed a significant downward trend.The average capita tuberculosis hospitalization expenses has been basically stable for the past five years, and it has remained at about 6,500 yuan. (2) Western drug fees and diagnostic costs are ranked first and second in the composition of hospital expenses, which are 43.66 % and 23.99 % respectively.The composition of integrated services showed a marked upward trend year by year, with annual growth rates of 18.73 per cent.  (3) Western drug expense is the most active factor in each year, with contribution rate of 26.04 %, and most of them are negative changes.Conclusion〓The tuberculosis hospitalization expenses were too high and the composition is unreasonable. Besides controlling the proportion of drugs, other measures should be performed to control the increase of total hospitalization expenses.