Abstract：Objective To study the effectiveness and safety of sulphate/hydrochloride glucosamine for osteoarthritis (OA).Methods Databases of Medline, Embase and Cochrane library were searched for randomised, doubleblind, placebo-controlled trials (RCTs) concerning glucosamine treatment of OA. Quality evaluation were assessed by Cochrane quality evaluation standards and Meta-analysis by using Rev Man 5.3 were performed.Results A total of 15 studies contributed to the meta-analysis, revealing a large degree of inconsistency among the trials in terms of pain-reduction outcome: the combined ES in glucosamine trials was -0.37, P<0.001. Further, the combined ES in glucosamine sulphate trials was -0.54, P<0.001, the combined ES in glucosamine hydrochloride trials was -0.04, P=0.22. And safety analysis showed that the adverse event rate in the glucosamine group was low.Conclusions Glucosamine is effective for pain reduction in patients with knee OA and has a good safety.
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