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| Significance of expression of LC3,Raptor and Rictor in papillary thyroid carcinoma |
| SUN Fanghong1,2, HE Shuang3, GAO Xiangqian3, WEN Feifei3, LI Yangyang3, WU Shuhua1,3 |
1 College of Basic Medical,Binzhou Medical University,Yantai 264003,P.R.China;
2 Department of Pathology, Zouping County Hospital of traditional Chinese medicine;
3 Department of Pathology, Binzhou Medical University Hospital |
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Abstract Objective To investigate the expression of LC3,Raptor and Rictor in papillary thyroid carcinoma and elucidate the relationship between LC3,Raptor,Rictor and cancer clinical pathological factors.Methods Immunohistochemical method was used to detect LC3,Raptor and Rictor expression.The relationship with expression of LC3,Raptor, Rictor and clinicopathological factors was analyzed.Results The positive rates of LC3,Raptor and Rictor in papillary thyroid carcinoma were 76.7, 82.5 and 41.7% respectively, but they were 4.9,16.5 and 7.8%, respectively in the adjacent tissues.The difference was statistically significant.LC3 was correlated with tumor size and psammoma bodies,High expressions of Raptor and Rictor were significantly correlated with TNM grade, and Rictor was correlated with lymph node metastasis.Conclusion The expression of LC3,Raptor and Rictor were up-regulated in papillary thyroid carcinoma, and they were considered to have potential value for the diagnosis and prognosis of papillary thyroid carcinoma.
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Received: 13 March 2018
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