Axl及Gas6在结肠癌中的表达与临床意义

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Abstract Objective To investigate the expression and clinical significance of receptor tyrosine kinases (Axl) and growth arrest-specific 6 (Gas6) in colon cancer,and discuss the role of Axl and Gas6 during the development and metastasis of colon cancer,and analyze their relationship.Methods The Axl and Gas6 expression was detected in 87 cases of normal,adjacent, and colon cancer tissues using immunohistochemical method to analyze the difference of Axl and Gas6 in three different tissues and the corresponding clinical pathological significance.Results The expression rate of Axl in 87 cases of colon cancer was 52.9%, which was significantly higher than that in normal tissues 33.3% and adjacent tissues 34.5%.The expression rate of Gas6 in 87 cases of colon cancer was 60.9%,which was significantly higher than that in normal tissues 37.9% and adjacent tissues 42.5%,and the expression of Axl and Gas6 was correlated with TNM stage and lymph node metastasis.Axl expression was positively correlated with Gas6 expression in colon cancer. Conclusions Axl, Gas6 protein were highly expressed in colon cancer tissues,they played an important role in the occurrence, development, invasion and metastasis of colon cancer.

Key words： Axl Gas6 colorectal cancer

Received: 04 June 2018

PACS:

R735.3+5

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	Articles by authors
	GUO Fengrui
	ZHOU Fengqiang
	XU Hong
	LI Xinjun
	HUANG Qishun

Cite this article:

GUO Fengrui,ZHOU Fengqiang,XU Hong, et al. Expression and clinical significance of Axl and Gas6 in colon cancer[J]. 滨州医学院学报, 2018, 41(5): 330-333.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/ OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2018/V41/I5/330

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