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25 June 2021, Volume 28 Issue 3
    

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  • Zhu Jingjing, Yu Yongfu, Xu Huilin, Qin Guoyou
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    Objective To evaluate the time-varying association between baseline BMI in patients with hypertension and cancer risk to provide recommendations for weight management in order to reduce the risk of cancer. Methods  We retrospectively selected 212 394 Chinese adults with hypertension from 2007 to 2015 in the Minhang District Electronic Health Information System (EHR) and used time-varying coefficients Cox regression model to estimate the time-varying association between baseline BMI and cancer risk. Results Multivariate Cox regression analysis showed that underweight was associated with a higher risk of cancer in hypertensive patients, and the magnitude of associations decreased from 1.65 (95%CI: 1.42-1.91) at 1 year of follow-up to 1.30 (95%CI: 1.19-1.41) at 5 years of follow-up, until 0.96 (95%CI: 0.85-1.08) at 10 years of follow-up. Overweight was associated with lower risk of cancer and the protective effects of overweight gradually attenuated over time from 0.86 (95%CI:0.80-0.93) at 1 year of follow-up to 0.94 (95%CI:0.90-0.97) at 5 years of follow-up, until 1.04 (95%CI:0.99-1.08) at 10 years of follow-up. Class I obesity had a relatively stable protective effect, with HRs at 1 year and 10 years of follow-up 0.86 (95%CI:0.82-0.90), and 0.87 (95%CI:0.83-0.90), respectively. Conclusion Management efforts for hypertension may target controlling body weight in a reasonable range for patients, and probably more attention should be given to underweight patients.
  • Liu Mengyang, Tian Yuan, An Ning, Zhang Liyuan, Wei Li, Liu Meina.
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    Objective To analyze the influencing factors of postoperative complications of breast cancer based on hospital level and patient level with the use of the twolevel logistic random effect model, so as to provide a basis for improving the quality of breast cancer treatment in the hospital and improving the prognosis of patients. Methods information questionnaire was formulated of breast cancer patients′ medical records, and the information of breast cancer patients′ cases was collected; univariate analysis was performed on the related factors of postoperative complications of breast cancer by t-test or chi-square test. The hospital as the two-level unit, the patient as the one-level unit, whether patients with postoperative complications as outcome variables, and the influence factors of complications as the explained variable, factors with statistical significance in univariate analysis included, two-level logistic random effect model was used for multivariate influencing factor analysis. Results Totally 3 224 patients were collected; the incidence of postoperative complications of breast cancer was 22.52%; the results of two-level Logistic random effect model showed that the hospital level random effect had statistical significance in the zero model (P<0.05). Among the explanatory variables at hospital level, hospital type (OR=0.130, 95%CI: 0.027-0.638) was statistically significant. Among the explanatory variables for patient level, age (OR=0.983, 95%CI: 0.972-0.994), residence (OR=0.671, 95%CI: 0.534-0.843), preoperative cytological examination (OR=1.973, 95%CI:1.397-2.787) and axillary lymph node metastasis (OR=1.435, 95%CI:1.168-1.762) were statistically significant (P<0.05).  Conclusion The younger the age, and women living in the city are the high-risk group of complications after breast cancer; in the process of postoperative
  • Zhao Peng, Wu Lichen, Yan Miaojia, Mi Baibing, Chen Fangyao, Yan Hong
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    Objecive To introduce the method of using empirical likelihood method to estimate the relevant parameters of accuracy evaluation of diagnostic test without a gold standard under conditional correlation hypothesis. Methods Based on the existing Hui-Walter model, the conditional simplified model is constructed, that is, under the conditional correlation hypothesis, the estimation of the relevant parameters of the diagnostic test evaluation is obtained by constructing the conditional likelihood function. Results By constructing the conditional likelihood function under the conditional correlation hypothesis, the method obtains reliable and robust estimates of related parameters, including the prevalence rate, sensitivity and specificity of the current sample.Conclusion This method simplifies the conditions for the analysis of the diagnostic test without a gold standard, expands the application range of evaluation of diagnostic test without a gold standard, and is a new and effective method to evaluate the accuracy of diagnostic test without a gold standard.
  • Zhao Yanfei, Chen Liqiao, Fang Jiaying, Ding Zan
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    Objective To explore the relationships between the concentrations of serum alanine aminotransferase (ALT) and the levels of systolic(SBP)and diastolic blood pressure(DBP)among adolescents. Methods From February 2018 to June 2019, 7 805 students were enrolled in 9 junior and senior high schools in S〖JP2〗henzhen. Stratified analyses were performed according to gender, age (10-13 years old or 14-17 years old) and serum ALT quartiles (≤ 9 U/L, 10-11 U/L, 12-15 U/L, or >15 U/L). Results The SBP of adolescents was (112.87±12.00) mmHg and average DBP was (71.68±9.61) mmHg among the 7 805 adolescents. The blood pressure of the male group was higher than that of the female group, with SBP (115.81 vs 109.23) mmHg and DBP (73.15 vs 69.86) mmHg (P<0.001); stratified analysis by quartile of serum ALT level showed that blood pressure increased with the increase of ALT level (P<0.001); the generalized additive model showed that there was a correlation between blood pressure and serum ALT level in adolescents, SBP-ALT (r=0.113-0.279, P<0.001), DBP-ALT (r=0.088-0.208, P<0.001); the results of binary logistic regression analysis showed that hypertension was associated with elevated serum ALT (OR=3.411, 95%CI: 2.215-5.251) and boys (OR=3.684, 95%CI:2.594-5.231) among adolescents. Conclusion There is a correlation between elevated blood pressure and elevated serum ALT levels in adolescence, and the local government should increase the vigilance to monitor the simultaneous elevation of blood pressure and ALT in middle school students.
  • Chen Lehui, Zhang Rui, Xue Dongmei, Wu Du
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    Objecive To analyze the relationship between serum γglutamyltransferase (GGT) levels and metabolic syndrome in the elderly population. Methods Totally 1 249 elderly people were selected who received physical examination in Hangzhou Wuyunshan Hospital from January 2017 to December 2019, and the relationship was analyzed between serum GGT and metabolic syndrome component and the risk of having metabolic syndrome. Results The serum GGT level was positively correlated with systolic blood pressure, diastolic blood pressure, fasting blood glucose and fasting triglyceride (P<0.05), and negatively correlated with high density lipoprotein cholesterol (P<0.05). Logistic regression analysis showed that the risks of metabolic syndrome in male serum GGT 21.50-28.35 U/L group, 28.36-39.50 U/L group and >39.50 U/L group were higher than those in <21.50 U/L group (OR=1.609, 3.120, 5.601, 95%CI: 1.028-2.516, 2.016-4.820, 3.562-8.789), and the risks of metabolic syndrome in female serum GGT 15.1019.37 U/L group, 19.38-26.95 U/L group, and>26.95 U/L group were higher than those in <15.10 U/L group (OR=1.844, 2.678, 3.769, 95%CI: 1.004-3.375, 1.481-4.825, 2.102-6.740). Conclusion Increased serum GGT level in the elderly is a risk factor for the onset of metabolic syndrome, and its increase in the normal range has been closely associated with the onset of metabolic syndrome.
  • Peng Lijun, Lin Zhi, Lin Xiaodan
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    Objecive To investigate the ICU safety climate and nurses′ perception of patient safety culture, and analyze the influence of ICU safety climate on nurses′ perception of patient safety culture. Methods Totally 275 ICU nurses from 4 hospitals in Wenzhou city were selected as the research subjects. Pearson method was used to analyze the correlation between safety climate and the perception level of ICU nurses′ safety culture. Multiple linear regression was used to analyze the influencing factors of the perception level of ICU nurses′ safety culture. Results The score of ICU safety climate was (83.28±13.85) points; the cognitive score of nurses′ safety culture was (133.96±30.85) points; Pearson correlation analysis showed that, there was a positive correlation between them (r=0.324, P<0.01); multiple linear regression analysis showed that, ICU nurses′ degree, participation in nursing safety related training and safety climate were the main influencing factors of perception of patient safety culture (β=31.628, -36.625, 0.260, P<0.05). Conclusion Safety climate is an important factor affecting ICU nurses′ perception of patient safety culture. ICU should adopt targeted strategies to create a good safety climate and improve nurses′ perception level of patients′ safety culture and nursing service quality.
  • Yang Yang, Zhao Li, Chen Jinbiao, Zhang Jing
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    Objective To analyze the composition and trend of inpatients with malignant tumors in a hospital from 2015 to 2019, and provide reference for the prevention and treatment of malignant tumors and the allocation of medical resources.Methods The medical records of patients with malignant tumors who were first hospitalized in this hospital from January 2015 to December 2019 were included in this study. Retrospective analysis was performed on the disease composition, sequence change trend, age and sex distribution of malignant tumors. Results Totally 60 682 patients with malignant tumors were admitted, including 33 672 males and 27 010 females, with a sex ratio of 1.25∶1. The average age of patients was (52.10±15.40) years old, and the incidence peak of malignant tumors was in the age group of 40-69 years old. Patients with malignant tumors increased year by year, and the annual growth rate was 4.38%. The top 10 malignant tumors were lung cancer, colorectal cancer, thyroid cancer, breast cancer, liver cancer, gastric cancer, malignant brain tumor, leukemia, lymphoma and oral cancer, accounting for 72.12%. The top 3 malignant tumors were lung cancer, colorectal cancer and liver cancer for male, and breast cancer, thyroid cancer and lung cancer for female. There were also differences of malignant tumors between different age groups. Conclusion The number of inpatients with malignant tumors in the hospital is on the rise. Relevant medical departments could adjust the prevention and treatment strategies and the allocation of medical resources according to the disease distribution characteristics and high-risk malignant tumors.
  • Wen Guohong.
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    Objective To analyze comprehensively the first hospitalization data of cervical cancer patients in a general hospital, to understand the time and cost, and to provide clues for the burden analysis of cervical cancer patients. Methods Home page data of cervical cancer hospitalization records from 2013 to 2018 were retrieved for retrospective analysis, age differences were analyzed by one-way anova, and drug proportion and consumable proportion differences were analyzed by chi-square test. Results There were totally 1 043 patients with cervical cancer, with an average stay of 18.88 d and an average hospitalization cost of 28 919.05 yuan, the average cost was about 54 979.18 yuan, including 682 surgical patients and 361 non-surgical patients. The number of discharged patients was the largest in the group of 40 years old and above, followed by the group of 50 years old and above. In 2013, drugs accounted for the highest proportion, the difference was statistically significant (χ2=695.00, P<0.05), and then decreased year by year. There was no statistical difference in the proportion of consumables. Conclusion Patients with cervical cancer need to spend a lot of time and cost in the hospital for the first time. Patients with surgery and operation have more time and cost, while patients with therapeutic operation have less time and higher cost burden. Early prevention, early examination and early treatment should be taken to reduce the burden of cervical cancer patients.
  • Su Yunxia, Li Xiaoxue, Wu Yingying, Wang Yuehong, Xu Xiaoxia, Wang Xian
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    Objecive To understand the use of monosialotetrahexosylganglioside sodium in a hospital, and analyze its rationality, so as to provide reference for clinical safety and rational drug use. Methods The use of monosialotetrahexosylganglioside sodium in inpatients in a hospital from January to December 2018 was analyzed retrospectively, and the rationality was analyzed according to the drug instructions, relevant guidelines and consensus. Results The DUI and DDDC of monosialotetrahexosylganglioside sodium were 1.71 and 169.41 yuan per day respectively. Most of the visited departments were neurosurgery, intensive care and rehabilitation. In 764 patients, their rational rate of indication, irrational usage and dosage, the irrational rate of treatment course, the irrational rate of clinical combined drug use, and the incidence of adverse reactions was 27.2%, 94.5%, 76.4%, 6.9% and 1.2%, respectively. Conclusion There are unreasonable phenomena in the use of monosialotetrahexosylganglioside sodium, the unreasonable problems such as indication, dosage and course of treatment are more prominent, and there are hidden worries about the safety of drug use. The use of monosialotetrahexosylganglioside sodium should be further regulated.
  • Wang Jian, Pang Jing, Lu Wenqiao
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    Objective and the characteristics of accidental injury in a hospital, and to provide scientific basis for the development of relevant prevention measures and intervention methods. Methods According to ICD-10 disease classification, an descriptive epidemiological study was performed on accidental injury hospitalized patients from 2009 to 2020.Results Among 48 204 inpatients with accidental injury, the sex rate of the male to female was 1.15∶1, the majority were aged 45 to 60 and over 60, with an average age of 51.00(36.00)years old, and the main occupation were farmers and workers; The top cause of accidental injury was fall, and the most common injured part of body was the knee and lower leg.Conclusion The key prevention groups of accidental injuries are men, people over 45 years old, farmers and workers; targeted intervention measures should be taken for fall to strengthen the publicity and education of accidental injury and self-protection awareness.
  • Jiang Jie, Ling Wen, Hu Anli
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    Objective To analyze the hospitalized death cases in a tertiary hospital in Anhui province, to identify case fatality rate, gender composition, age distribution, and death sequence, so as to provide references for the hospital management. Methods The first pages of the medical records of the patients who died in the hospital from 2009 to 2019 were collected, and the international statistical classification ICD-10 was used to classify the discharge diagnoses, in order to clarify the mortality rate, death distribution and death sequence in the hospital, and Chisquare test was used to analyze and compare the data. Results From 2009 to 2019, the inpatient mortality rate of the hospital was 0.72%, which remained the same as that of the previous year in 2014 and slightly increased in 2015. The overall trend of mortality was decreasing year by year. The female mortality rate was significantly lower than that of the male, and the number of deaths in the age group ≥80 years old was the largest. The top three causes of death were malignant tumors, respiratory system diseases and circulatory system diseases. Conclusion To improve the health awareness and health literacy of the elderly and men, medical institutions need to strengthen the construction of oncology, respiratory medicine and other disciplines, improve the level of medical services, and reduce the case fatality rate.
  • Zhang Yaoguang, Wu Shiyong
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    Objective To analyze the level and distribution of the direct economic burden caused by smoking in China, and to provide the basis for making relevant policies. Methods Using epidemiological methods, data from the Sixth National Health Service Survey 2018 were used to analyze the direct economic burden attributable to smoking, as well as the direct economic burden of diseases in different age groups and diseases. Results The direct economic burden of smoking was 82.63 billion yuan in 2018, up 93.0% from 42.80 billion yuan in 2008, with an average annual growth rate of 6.8%. The economic burden of cardiovascular and cerebrovascular diseases was 41.34 billion yuan, accounting for 50.1% of the total economic burden; the economic burden of malignant tumors was 25.86 billion yuan, accounting for 31.3% of the total economic burden. Conclusion The direct economic burden caused by smoking is rising rapidly, so it is necessary to further strengthen policies related to tobacco control and disease prevention, in order to reduce the burden of diseases, and improve the health status of the whole population.
  • Zhao Xiangjuan, Dong Yuyan, Wu Ximei, Gao Jie
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    Objective To explore the association between adult waist circumference(WC)  variability and incident hypertension, and to provide evidence for the health management of obesity and the early prevention of hypertension. Methods Based on the longitudinal cohort data of China health and nutrition survey from 1989 to 2011, 5 723 subjects aged 20-60 years old with more than 4 times of WC measurements before onset of hypertension were selected. The mean follow-up period was 11.6 years, during which 1 415 incident hypertension patients were observed. Four WC variability indexes were calculated, including standard deviation, coefficient of variation, range and linear slope. Multivariate logistic regression was used to analyze the association between WC variability and incident hypertension. Results After adjusting for the covariates (including baseline waist circumference level), the association between WC variability and incident hypertension was statistically significant. The standardized OR of WC standard deviation, coefficient of variation, range and linear slope were 1.02 (95%CI: 1.01-1.03), 1.01 (95%CI: 1.00-1.03), 1.01 (95%CI: 1.00-1.03) and 1.05 (95%CI: 1.04-1.06), respectively. Compared with the reference group (Q1), the OR value for upper three quartiles (Q2、Q3、Q4) of the WC linear slope was 1.06, 1.11 and 1.14, respectively, which showed a significant linear trend (P-trend<0.05). Conclusion Rapid increase and great variability in waist circumference during early adulthood appear to be independent risk factors for hypertension, which is independent of waist circumference level.
  • Zhou Wangzhan, He Wei, Hu Yunshuang, Zhao Feng, Huang Jianfang
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    Objective To understand the epidemic situation of influenza A and influenza B in Wenzhou from 2017 to 2019. Methods The throat swabs and clinical data of influenzalike cases from January 2017 to December 2019 in two hospitals in Wenzhou were collected to analyze the number of influenza-like cases and the detection rate of influenza-like cases by gender, age, month and year. Results The number of influenza like cases received from 2017 to 2019 was 32 097, including 2 355 cases (7.3%) in 2017, 8 177 cases (25.5%) in 2018 and 21 565 cases (67.2%) in 2019. The detection rates in 2017, 2018 and 2019 were 44.4%, 35.8% and 39.7% respectively. The detection rates of influenza A were 6.6%, 15.5% and 27.2%, respectively, showing an increasing trend year by year. The detection rate of influenza B was 37.8%, 20.3% and 12.4%, respectively, which decreased year by year. There were 16 750 males (52.1%) and 15 347 females (47.9%) in 32 097 cases of influenza like diseases. From 2017 to 2019, the total detection rate of men was higher than that of women (P<0.001), and the detection rate of influenza A in men was higher than that in women (P<0.001). There was no significant difference between male and female (P=0.408). The age group of 4 to <7 years old and group of 7 to <19 years old were the main groups of influenza epidemic. The highest detection rate was found in the 7 to <19 age group, and the detection rates from 2017 to 2019 were 53.1%, 43.7% and 49.4% respectively. From 2017 to 2019, influenza epidemics were mainly distributed in January, February, March and December, and influenza A and B alternated. Conclusion From 2017 to 2019, influenza A and influenza B alternated in Wenzhou, and winter and spring were the peak periods of influenza; men are more likely to be infected with influenza A than women; The age group of 7 to <19 years old is the main group of influenza, which suggests that the prevention and control of influenza in campus should be done well.
  • Sun Cong, Liu Haixia, Fan Siyu, Lü Peng
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    Objective To explore the public cognition, attitude and stress response to COVID-19.Methods The self-compiled public cognition and attitude questionnaire on COVID19 and the stress response scale (SQR) were used to carry out the questionnaire survey with online Wenjuanxing. The data were analyzed by SPSS 22.0 statistical software, and t test, t′ test, and rank sum test were used to compare the stress response between groups. Results Among the respondents, 74.7% of them knew the disease very well or relatively well; the main way of understanding the disease was the network (31.6%); 63.2% of them paid close attention to the epidemic, mainly the reports of the progress of the epidemic, self-prevention measures and scientific research; the stress scores of expressing concern and panic over the pandemic (t=5.21, P<0.001) and spreading prevention knowledge (t=5.31, P<0.001) were higher; the influence of the epidemic on oneself and his family (SR: H=32.34, P<0.001; FER: H=24.49, P<0.001; FPR: H=27.11, P<0.001; FBR: H=26.60, P<0.001), and the attitude towards the infected people or the patients who returned from Wuhan (SR: H=12.17, P<0.001; FER: H=13.22, P<0.001; FPR:H=9.46, P<0.001; FBR: H=9.48, P<0.001) had influence on the total score of stress response and the scores of each dimension. Conclusion The public cognition of and attention to COVID-19 is high, and their attitude is positive. The interaction of the public on the network platform, the possible influence on the family members of the new coronavirus, and the attitude towards the infected people or people returning from Wuhan have influence on the stress response.
  • Yu Xiaohong, Cui Fangfang, Zhai Yunkai
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    Objective To analyze the operation and management of telemedicine services in secondary hospitals in China, and to provide scientific basis for the effective operation of telemedicine in secondary hospitals. Methods The probability proportionate to size sampling (PPS) was adopted to investigate the telemedicine operation and management in secondary hospitals across the country from August to October 2018. Chi-square test and analysis of variance were used to compare the differences in telemedicine operation and management of secondary hospitals in different regions. Results The telemedicine operation and management information of 187 secondary hospitals in 29 provinces, autonomous regions and municipalities were collected from the survey. The number of telemedicine staff in secondary hospitals was mainly between 0 and 5, and the annual investment was mainly under 20 000 yuan, accounting for 49.17%. And 69.52% of secondary hospitals adopted a completely self-managed operation model, and 65.24% of secondary hospitals had established telemedicine private network. The main types of telemedicine services conducted in secondary hospitals were remote consultation, remote education and remote specialist diagnosis, and 83.42% of secondary hospitals had implemented remote comprehensive consultation services. Conclusion The secondary hospitals mainly adopted independent operation mode to carry out telemedicine service in China. Most hospitals have established telemedicine private networks and carry out remote consultation services. However, the construction of telemedicine management department, network and information systems, and the application of telemedicine services in secondary hospitals need to be further strengthened.
  • Zhou Chaohua, Xia Xiaoqiong, Wu Xiaoyun, Peng Cheng, Ye Xiufeng
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    Objective To predict the current situation of the allocation of health human resources in Shenzhen with the use of the grey regression coupling model, and to provide reference for the formulation of relevant health policies. Methods SPSS 19.0 statistical analysis software was used to construct a linear regression model between the number of practicing (assistant) physicians per thousand population and the number of registered nurses per thousand population and influencing factors. Excel formula programming was used to establish a grey prediction model to predict the influencing factors, and finally the predicted value was substituted into the linear regression model for coupling prediction. Results 2019, the number of practicing (assistant) physicians per thousand population was 3.01, an increase of 46.11% over 2007, with an average annual growth rate 3.21%; the number of registered nurses per thousand population was 3.30, an increase of 68.37% over 2007, with an average annual growth rate 4.44%. The accuracy of the grey prediction model was level 1 (excellent), and the number of practicing (assistant) physicians per thousand population from 2020 to 2025 was 3.05, 3.23, 3.44, 3.68, 3.96, and 4.19, and the number of nurses per thousand population from 2020 to 2025 was 3.49, 3.70, 3.92, 4.18, 4.46, and 4.73 respectively. Conclusion From 2020 to 2025, the required number of health human resources in Shenzhen would show an increasing trend. This prediction result could provide a scientific reference for the allocation of health human resources.
  • Li Hui, Li Xiaoli, Kong Bin, Liu Rui, Shen Xiaorong
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    Objective To analyze and evaluate the utilization efficiency of beds in 44 wards of a tertiary hospital in 2019, and provide data for performance evaluation, rational allocation of resources and scientific decision-making by the leadership. Methods Data indicators in 2019 were selected in the statistical work report of a hospital. TOPSIS method and the RSR rank-sum ratio method were used to analyze and evaluate the bed utilization in each ward, and the correlation was analyzed between the analysis results of the two methods. Results There is a strong correlation between the consistency of the results of the two evaluation methods, with r=0.923 and P<0.05, and the top and bottom wards are almost completely consistent. The overall data show the shape of jujube nuclei with two small ends and a large middle, and they conform to general social laws. Conclusion When five indicators of the two algorithms are used to evaluate the utilization rate of beds, the results are scientific and credible and have reference value. The leadership should adopt corresponding deployment measures for different efficiency departments to maximize the use of resources while avoiding waste.
  • Zhou Mingyou
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    Objective To study the trend and characteristics of medical income change of a tertiary hospital in Zhejiang province from 2016 to 2019, to find the main factors affecting the medical income change, and to provide feasible suggestions for the hospital to optimize the income structure. Methods The data were analyzed by structural variability analysis. Results The main five items affecting the change of outpatient income structure from 2016 to 2019 were western medicine income, other income, laboratory income, Chinese patent medicine income and examination income. The main five items affecting the change of inpatient income structure from 2016 to 2019 were western medicine income, material income, surgery income, laboratory income and other income. Conclusion The drug income and the laboratory income are the main factors affecting the change of the medical income structure of the hospital. The proportion of health material income and medical service income is unreasonable. The hospital management department should take reasonable measures to make the medical income structure more reasonable.
  • Wang Xiang, Lu Qin
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    Objective To fully excavate various data of the hospital business system, improve the utilization of data resources, and provide strong data support and decision support for clinical, scientific research and management of the hospital. Methods A large number of temporary data proposed by various departments of the hospital can be quickly counted through SQL statements to improve the efficiency of statistical work. Results SQL statement realizes the statistical work of hospital data and ensures the accuracy of data. Conclusion The flexible use of SQL statements can help hospitals greatly improve the efficiency and data utilization in data statistics.
  • Lin Jianchao
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    Objective To explore the realization of the gray model GM(1,1) in Excel. Methods Excel was used to compile the GM (1, 1), and the model was validated by the time series of nursing human resource needs. Results With the use of Excel, the GM(1,1) can be quickly and accurately compiled and used for extrapolation prediction. Conclusion The successful realization of gray model in Excel provides methodological reference for forecasting time series data.