Xin Zhizhen, Zheng Xueying, YaoYe
Objective To explore the relationship between healthy sleep patterns and the risk of peptic ulcer, with a view to early prevention and relevant interventions.Methods A total of 357,636 participants from the UK Biobank were included in this study. Healthy sleep patterns were defined to include sleep duration, sleep chronotype, insomnia, snoring, and daytime napping. The Cox proportional hazards model was used to assess the association between healthy sleep patterns and the risk of peptic ulcer.Results Healthy sleep patterns were associated with a reduced risk of peptic ulcer (HR=0.88, 95% CI: 0.86–0.89), gastric ulcer (HR=0.86, 95% CI: 0.84–0.89), and duodenal ulcer (HR=0.89, 95% CI: 0.86–0.92). Specifically, sleep duration of 7–8 hours per day (HR=0.82, 95% CI: 0.79–0.85), morning chronotype (HR=0.91, 95% CI: 0.87–0.94), infrequent insomnia (HR=0.78, 95% CI: 0.74–0.81), and infrequent daytime napping (HR=0.75, 95% CI: 0.68–0.82) were all associated with a reduced risk of peptic ulcer. The results of subgroup analysis stratified by baseline characteristics were consistent with the overall model.
Conclusion Having healthy sleep patterns is associated with a reduced risk of peptic ulcer, gastric ulcer, and duodenal ulcer. Therefore, taking effective measures to improve sleep behavior is of positive significance for the public to prevent peptic ulcer.