Objective To retrospectively analyze the inpatient death cases in a tertiary general hospital, so as to understand and master the death situation and causes of inpatients in the hospital in recent years, and provide a scientific and reasonable management basis for the hospital. Methods The inpatient death cases in a tertiary general hospital from 2021 to 2023 were collected and retrospectively analyzed from the aspects of age, gender, department, and disease diagnosis at death. Results There were 819 death cases in this hospital from 2021 to 2023, with a total inpatient mortality rate of 0.58%. The male-female ratio was 1.96:1, and those aged 60 and above accounted for 82.42%. The departments with the most deaths were mainly ICU, Department of Cardiology, Department of Respiratory Medicine, and Department of Neurosurgery. The top three diseases were tumors, circulatory system diseases, and respiratory system diseases. Conclusion With the aggravation of population aging, tumors, circulatory system diseases, and respiratory system diseases have become the main causes of inpatient death in this hospital, and elderly patients are the key objects that need attention.