Xie Biao, Qu Siyang, Xiang Jing, Luo Xiao, Wang Wenji, Liu Meina
Objective The aim of this study is to assess the associated factors of Henoch-Schonlein purpura(HSP) in Chinese children. This study has important public implications for developing strategies of preventing HSP. Methods In this hospital-based, case-control study, we recruited 353 HSP cases and 61 control participants during 2012 and 2015. We collected related information of 414 HSP in children and the control group through questionnaires. Student′s t-test, Pearson Chi-square test and Wilcoxon test were used respectively to compare the difference between the case and control group; We applied logistic regression model to analyze the associated factors of HSP in children. Results Univariate analysis revealed that the differences in age, mother and father′s level of education were significant between the case and control group. Univariate analysis also revealed that the differences in diet regularity, eating cold, fried and spicy food, meat, drinks, milk and dairy products, fruits and vegetables between the two groups were statistically significant. Similarly, the differences in way of birth, breast-feeding, mixed feeding and mother contacting harmful substances before becoming pregnant between the two groups were statistically significant. After the adjustment of age, sex and mother′s level of education, multivariate Logistic regression demonstrated that living in rural areas, the enough sleep time, consumption frequencies of fruit, sweet and meat and mother′s level of education were protective factors for HSP in children. Multivariate Logistic regression also demonstrated that mixed feeding, feeding after chewing, illness during pregnancy, and consumption frequencies of cold, spicy food and nuts were the risky factors for HSP. Conclusion Sufficient sleep time, less cold and spicy food and plenty of meat and fruit can reduce the risk of HSP in children. Advocating breastfeeding, avoid feeding after chewing can also prevent children from HSP.
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