Objective  To understand the current status of social support for medical staff in the epidemic of the corona virus disease 2019 (COVID-19) and explore its influencing factors, in order to improve the social support of medical staff and provide a scientific basis for improving their physical and mental health. Methods General information questionnaires and social support rating scale (SSRS) were used to conduct an online questionnaire survey on 707 medical staff in 6 secondary and higher hospitals in Taizhou to understand the current social support status of medical staff in the epidemic situation. Univariate analysis and binary logistic regression analysis were used to analyze the influencing factors. Results The recovery rate of the effective questionnaires was 98.16%, and the total score of the social support scale of 694 medical staff was (35.20±7.33), which was not statistically different from the domestic norm score (34.56±3.73) (P=0.335). Medical staff with old age, high professional title and high family income per capita and married had higher total scores of social support, subjective support dimensions, and objective support dimensions than others (P<0.05); the total score of social support, the scores of subjective support dimension and objective support dimension, and support utilization dimension score of medical staff without fear of new coronary pneumonia, without sense of conscious uselessness, and with high sleep quality were higher than those in other groups (P<0.05). The analysis results of the influencing factors of low-level social support of medical staff showed that married medical workers (OR=0.25, 95%CI: 0.10-0.62) and those with high sleep quality (OR=0.34, 95%CI: 0.11-1.00) were less likely to obtain low level of social support, which was a protective factor. Conscious uselessness (OR=2.59, 95% CI: 0.93-7.19) was a risk factor. Conclusion Under the epidemic situation, medical staff had received due social support, and there were many influencing factors. Emphasis should be placed on the social support of medical staff who are unmarried/ divorced, poor sleep quality or have a strong sense of uselessness to better meet the needs of their physical and mental health.