TSHR基因多态性与不同临床亚型的Graves′病治疗预后的关系

doi:10.3969/j.issn.1006-5253.2018.03.001

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Abstract Objective To investigate the relationship between thyroid stimulating hormone receptor (TSHR) gene polymorphism and the prognosis of Graves′ disease (GD) after antithyroid drugs(ATD)treatment in Weifang Han Chinese population of Shandong province. Methods A total of 1 961 patients diagnosed GD who were referred to the Endocrinology Clinic and 533 controls were included in to study from January 2010 to January 2015. By case-control study, the SNP was genotyped by Taqman probe technique on ABI QuantStudio^TM 5 real-time PCR system respectively. SPSS 24.0 was used to make statistical analysis. Results According to the study, the SNP site rs179247-A of the TSHR gene intron 1 region was demostrated significantly correlated with GD(P_Allelic＜0.001,OR=1.64,95% CI=1.42～1.89). Analysis of model of inheritance suggested that the dominant model should be preferred for rs179247(P_Dominant＜0.001). However, there was no association between the SNP site rs179247 and different clinical subtypes of GD after antithyroid drugs treatment for at least 24 months(P_Genotypic=0.553). Conclusion Our findings demonstrated that the SNP site rs179247 of the TSHR gene intron 1 region was associated with GD, rs179247-A was an independent pathogenic site.However,there was no association between the SNP site rs179247 and different clinical subtypes of GD.

Key words： Graves′ disease antithyroid agents single nucleotide polymorphism thyrotropin receptors

Received: 14 March 2018

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	Articles by authors
	Zhang Ying
	Liu Lin
	Shen Min
	Li Rujiang
	Lu Hongwen

Cite this article:

Zhang Ying,Liu Lin,Shen Min, et al. The relationship between TSHR gene polymorphism and the prognosis of Graves′ disease in different clinical subtypes[J]. journal1, 2018, 25(3): 161-164.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2018.03.001 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2018/V25/I3/161

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