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| Investigation on correlated factors affecting the relapse of bipolar disorder |
| Liu Huiguo, Liu Lingjiang, Zheng Tianming |
| Affective Disorder Ward of Kangning Hospital in Ningbo City, Ningbo 315201, China |
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Abstract Objective To explore the causes and correlated factors of the relapse of bipolar disorder, and to provide basis for early treating of bipolar disorder and preventing of relapse. Methods With case-control study method, 96 confirmed cases with bipolar disorder were divided into case group and control group according to relapse, and we collected possible correlated factors of the relapse of bipolar disorder through following-up. Then, single factor and multiple factors analysis methods were used to screen influencing factors of bipolar disorder. Results The incidence rate of relapse of bipolar disorder in 2 years was 51.0% (49/96). Multiple factors analysis result showed that the protective factors of the relapse of bipolar disorder included use of mood stabilizer (OR=0.157), use of antipsychotics (OR=0.258) and long-term use of stabilizer (OR=0.207), while the risk factors of the relapse of bipolar disorder contained long-term use of benzodiazepine (OR=3.931), somnipathy (OR=7.001) and delayed first treatment (OR=3.607). Conclusion There is a high relapse rate of bipolar disorder, and it is intimately correlated with rationality and sufficiency of medication, substance abuse, somnipathy, delayed first treatment, somatic disease and life events.
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Received: 21 September 2015
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