基于重复测量方差分析观察黄葵胶囊联合氯沙坦钾治疗糖尿病肾脏病Ⅲ期的临床疗效

doi:10.3969/j.issn.1006-5253.2022.05.003

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Abstract Objective To explore the clinical effect of Huangkui capsule combined with losartan potassium in the treatment of diabetic kidney disease stage Ⅲ by using repeated measurement analysis of variance (ANOVA).Methods Patients with stage Ⅲ diabetic kidney disease were divided into the experimental group (n=43) and the control group (n=43) by random number table method. All patients received the same basic treatment, the control group was given losartan potassium treatment, and the experimental group was treated with Huangkui capsule besides the treatment in the control group. The 24-hour urinary protein(Upro), urinary kidney injury molecule-1 (Ukim-1), and Urinary β-2-microglobulin (Uβ-2-MG) were measured before the treatment, 4 weeks after the treatment, 8 weeks after the treatment, and 12 weeks after the treatment in both groups, and the difference of TCM clinical syndrome scores between the two groups was evaluated before the treatment and 12 weeks after the treatment.Results The results of repeated measurement ANOVA showed that the time effect, inter group effect and interaction effect of Upro and Uβ-2-MG in the two groups were statistically significant (P<0.05), and only the time effect of Ukim-1 in the two groups was statistically significant (P<0.05). The results of one-way repeated measurement ANOVA showed that the levels of Upro and Uβ-2-MG in the experimental group and the control group had different trends with the treatment time. The results of multivariate analysis of variance showed that the level of Upro in the experimental group was lower than that in the control group at 4 weeks, 8 weeks and 12 weeks after the treatment (P<0.05). The level of Uβ-2-MG in the experimental group at 8 weeks and 12 weeks after the treatment was lower than that in the control group (P<0.05). After 12 weeks of the treatment, the TCM clinical syndrome score in the experimental group was significantly lower than that in the control group (P<0.05).Conclusion Huangkui capsule combined with losartan potassium is superior to losartan potassium alone in the treatment of stage Ⅲ diabetic kidney disease.

Key words： repeated measurement analysis of variance Huangkui capsule losartan potassium diabetic kidney disease

Received: 29 March 2022

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	Wang Wenwen
	Lin Yongqiang
	Wang Chaochao
	Jiang Yi

Cite this article:

Wang Wenwen,Lin Yongqiang,Wang Chaochao, et al. Clinical efficacy of Huangkui capsule combined with losartan potassium in the treatment of diabetic kidney disease stage Ⅲ by using repeated measurement analysis of variance[J]. journal1, 2022, 29(5): 331-336.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2022.05.003 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2022/V29/I5/331

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