某三甲精神病专科医院265例精神类药物不良反应回顾性分析

doi:10.3969/j.issn.1006-5253.2022.04.007

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Abstract Objective To analyze the characteristics, influencing factors and potential risks of adverse drug reactions (ADR) in a tertiary psychiatric hospital, so as to provide reference for clinical prevention and disposal of adverse drug reactions of psychotropic drugs.Methods A retrospective analysis was conducted on 265 ADR case reports due to the use of psychotropic drugs reported by a psychiatric hospital from October 2019 to October 2021.Results Among the 265 reported cases with ADR, 88 were males and 177 were females, with a higher incidence among females. The average age of the patients was (42.23±17.54) years old, with the majority being young and middle-aged. Forty drugs were involved in ADRs reports, of which the number of adverse reaction reports of antipsychotics was the largest, accounting for 66.42%, followed by antidepressants, accounting for 20.38%. The top three drugs in the cumulative number of reported ADR cases were Olanzapine, Quetiapine and Risperidone respectively. The system most affected by ADRs was the digestive system, with 105 cases reported, accounting for 37.23%, followed by the nervous system, with 88 cases reported, accounting for 31.21%.Conclusion The forms of adverse reactions caused by psychiatric drugs are various, and it is difficult to identify them. Clinicians should strengthen the monitoring of the use of psychiatric drugs and use the psychiatric drugs reasonably to ensure the medication safety.

Key words： adverse drug reaction psychotropic drug retrospective analysis

Received: 19 April 2022

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	Wu Xuqi
	Sun Ting

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Wu Xuqi,Sun Ting. Retrospective analysis of 265 cases with adverse reactions to psychotropic drugs in a tertiary psychiatric hospital[J]. journal1, 2022, 29(4): 270-274.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2022.04.007 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2022/V29/I4/270

［1］何淼泉，吴思霖，肖京平，等．对某住院患者使用抗精神病药物致不良反应报告的分析［J］．中国医院药学杂志，2019，39(18)：1888-1892．DOI:10.13286/j.cnki.chinhosppharmacyj.2019.18.16.
［2］FERNER R, ARONSON J. Susceptibility to adverse drug reactions［J］. Br J Clin Pharmacol, 2019, 85(10):2205-2212. DOI:10.1111/bcp.14015.
［3］KANAGARATNAM L, DRAME′ M, TRENQUE T, et al. Adverse drug reactions in elderly patients with cognitive disorders: A systematic review［J］. Maturitas, 2016, 85:56-63. DOI:10.1016/j.maturitas.2015.12.013.
［4］ONDER G, GAMBASSI G, SCALES C J, et al. Adverse drug reactions and cognitive function among hospitalized older adults［J］. Eur J Clin Pharmacol, 2002, 58(5):371-377. DOI:10.1007/s00228-002-0493-y.
［5］赵靖平，施慎逊．中国精神分裂症防治指南［M］．2版．北京：中华医学电子音像出版社，2015．
［6］马敏康，吕小琴，耿梦纯．8种不同非典型抗精神病药严重不良反应对比研究［J］．中国药物警戒，2020，17(5)：290-295．DOI:10.19803/j.1672-8629.2020.05.07.
［7］毛叶萌，黄堃，张明岛．上海地区45家医院2006—2010年抗精神病药利用分析［J］．中国药房，2011，22(22)：2026-2030．
［8］TODOROVIC〖DD(-*2〗′〖DD)〗 VUKOTIC〖DD(-*2〗′〖DD)〗 N, DORDEVIC〖DD(-*2〗′〖DD)〗 J, PEJIC〖DD(-*2〗′〖DD)〗 S, et al. Antidepressants- and antipsychoticsinduced hepatotoxicity［J］. Arch Toxicol, 2021, 95(3):767-789. DOI:10.1007/s00204-020-02963-4.
［9］邵青，张晓红，权伟，等．抗精神病药物引起的不良反应回顾性分析［J］．中国医药导报，2021，18(14)：156-159．
［10］杨欣湖，郑伟，蔡东滨，等．抗精神病药物所致高催乳素血症的影响因素及识别策略［J］．中国健康心理学杂志，2019，27(1)：156-160．DOI:10.13342/j.cnki.cjhp.2019.01.041.
［11］MONTEJO- L, ARANGO C, BERNARDO M, et al. Multidisciplinary consensus on the therapeutic recommendations for iatrogenic hyperprolactinemia secondary to antipsychotics［J］. Front Neuroendocrinol, 2017, 45:25-34. DOI:10.1016/j.yfrne.2017.02.003.
［12］肖逸丽，王汉光，高镇松，等．213例抗精神病药物不良反应分析［J］．中国医院药学杂志，2016，36(11)：930-932．DOI:10.13286/j.cnki.chinhosppharmacyj.2016.11.14.
［13］ENGLISH T, CASTLE D. Treating schizophrenia: Should we emphasise 'first do no harm'? ［J］. Aust N Z J Psychiatry, 2022, 56(1):8-10. DOI:10.1177/00048674211025696.
［14］WANG J, JIANG F, YANG Y T, et al. Off-label use of antipsychotic medications in psychiatric inpatients in China: A national real-world survey［J］. BMC Psychiatry, 2021, 21(1):375. DOI:10.1186/s12888-021-03374-0.