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| Research status of pragmatic randomized controlled trials in China |
| Lü Zhijie1, Wu Li2, Li Qiushuang2, Liu Shan2 |
1 Sir Run Run Show Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China;
2 The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China |
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Abstract Objective To review the published literatures on the pragmatic randomized controlled trials (pRCT) in China and to analyze the current status and hotspots of pRCT research. Methods The literatures of pRCT published by Chinese scholars from CNKI, Wanfang and Web of Science were reviewed since the establishment of the database to 31 July 2021. CiteSpace software was utilized to analyze the authors, institutions, keywords, and burst terms. Results Totally 196 Chinese and English literatures were published, and the number of articles was increasing year by year, with 79 Chinese literatures distributed in 44 journals and 117 English literatures distributed in 71 journals. The Institute of Clinical Basic Medicine of China Academy of Chinese Medical Sciences (7 articles) published the most Chinese literatures, while the University of Hong Kong (34 articles) published the most English literatures (34 literatures). The clustering label words of Chinese literature were clinical trial, RCT, evidence-based medicine, comprehensive scheme of Traditional Chinese Medicine (TCM), clinical trial scheme, clinical research and pharmacoeconomics. The clustering results of English literature needed to be further condensed. There were 4 and 5 burst terms in Chinese and English literatures respectively, which lasted for only from 1 to 3 years. Conclusion research hotspots of pRCT in China mainly focused on four fields, namely comprehensive clinical trial program of TCM, clinical trial in real world research, evidence-based medicine and pharmacoeconomics. However, the core authors of the research were few, the research institutions were scattered, and inter-agency cooperation needed to be strengthened.
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Received: 18 September 2021
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