Objective International Classification of Diseases(ICD-10) homepage coding system and other information systems were used to establish a colon cancer database, and the credibility of the cohort was verified through survival analysis. Methods Patients with colon cancer admitted to the hospital between January 2013 and December 2019 were extracted by ID numbers from the ICD-10 homepage coding system, the cancer reporting system database and the pathology database, respectively. The three databases were then cleaned and merged to create the colon cancer cohort. The pathological staging of the colon cancer cohort was performed to analyze the prognosis of colon cancer.Results Totally 1 148 patients with colon cancer were screened and obtained from ICD-10 home page coding system; 1 060 colon cancer patients were screened and enrolled from the pathological database, which was combined with ICD-10 home page coding system database to form a pathological record database; finally, a cohort of 581 colon cancer patients was generated by intersections with 831 colon cancer patients screened from the cancer report card database. A survival analysis of the cohort found that the center's colon cancer database matched the results of other studies.Conclusion It is credible to establish a tumor cohort by using the existing ICD-10 homepage coding system, the pathology system of the hospital and the cancer reporting and follow-up system established by the center for disease control and prevention. And expanding this model would help build colon cancer databases nationwide.