Objective To carry out data quality project in Shenzhen city, to realize standardization of regional medical statistical indicators and informatization of data collection, so as to ensure accuracy, integrity, timeliness and consistency of data.Methods System theory and control theory were used to standardize the data source and collection process of medical and health  statistical indicators.Results The meaning, statistical caliber, statistical algorithm and operation scripts of 53 key medical and health statistical indicators of outpatient emergency treatment and hospitalization were standardized. Through testing and verification, the standard document Specifications for Data on Health and Medical Statistics was formulated and released. By means of informatization, the informatization of data collection, standardization of operation and homogeneity of results of 53 indicators of public hospitals in the city were realized.Conclusion Study and realization of data standard for regional medical and health indicators in Shenzhen ensured the consistency of statistical results between the hospital and the central platform, improved data quality, provided technical support for the implementation of health industry standard, and maximized the value of medical data information.