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| Investigation on distribution of pathogenic bacteria in wounds of traumatic fracture infection and analysis of related drug resistance |
| Wang Hongxia1, Wang Xiaohuai2,Qiu Yanfen1 |
1.Department of Clinical Laboratory, Hangzhou Plastic Surgery Hospital, Hangzhou 310000, China;
2.Department of Clinical Laboratory, Zhejiang Armed Police Corps Hospital |
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Abstract Objective To study the distribution of pathogenic bacteria in wounds of traumatic fractures and related drug resistance, in order to provide guidance for the rational application of antibacterial drugs.Methods Totally 3 154 patients with traumatic fracture complicated with wound infection treated in our hospital from July 2017 to October 2018 were observed in this study.The general data of the patients were collected, and the distribution and drug resistance of pathogenic bacteria in the wounds of infected wounds were analyzed.Results A total of 3 154 pathogenic bacteria were isolated from infected wounds in 3154cases with traumatic fractures.Among them, 2 129 cases of strains (67.5%) were detected gram-positive bacteria, mainly staphylococcus aureus and staphylococcus epidermidis, and 984 cases of strains (31.2%) were detected gramnegative bacteria, mainly Escherichia coli and Enterobacter cloacae. The Staphylococcus aureus and Staphylococcus epidermidis were highly sensitive to linezolid, ampicillin, tigecycline and nitrofurantoin, and the drug resistance rate was 0.0%. And Staphylococcus epidermidis was highly sensitive to ciprofloxacin, and the drug resistance rate was 0.0%. However, the resistance rate of Staphylococcus aureus and Staphylococcus epidermidis to penicillin was 100%. At the same time, the resistance rates of Staphylococcus aureus and Staphylococcus epidermidis to other antibiotics were under 50%. Escherichia coli resistance to cefazolin, ampicillin, sulbactam, ceftriaxone, extendedspectrum β-lactamase, levofloxacin was over 70%, but for erythromycin and imipenem, Piperacillin, amikacin, ertapenem it was non-resistant. Enterobacter cloacae was not resistant to imipenem, but the resistance rate to other 15 antibacterial drugs was over 20%.Conclusion The distribution of pathogenic bacteria in wounds of traumatic fractures is mainly gram-positive bacteria such as Staphylococcus aureus and Staphylococcus epidermidis. The clinical treatment needs to select antibiotics according to the results of drug resistance analysis to avoid the outbreak of infection.
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Received: 27 February 2019
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