硫酸/盐酸氨基葡萄糖治疗骨关节炎的Meta分析

doi:10.3969/j.issn.1006-5253.2019.01.002

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Abstract Objective To study the effectiveness and safety of sulphate/hydrochloride glucosamine for osteoarthritis (OA).Methods Databases of Medline, Embase and Cochrane library were searched for randomised, doubleblind, placebo-controlled trials (RCTs) concerning glucosamine treatment of OA. Quality evaluation were assessed by Cochrane quality evaluation standards and Meta-analysis by using Rev Man 5.3 were performed.Results A total of 15 studies contributed to the meta-analysis, revealing a large degree of inconsistency among the trials in terms of pain-reduction outcome: the combined ES in glucosamine trials was -0.37, P<0.001. Further, the combined ES in glucosamine sulphate trials was -0.54, P<0.001, the combined ES in glucosamine hydrochloride trials was -0.04, P=0.22. And safety analysis showed that the adverse event rate in the glucosamine group was low.Conclusions Glucosamine is effective for pain reduction in patients with knee OA and has a good safety.

Key words： osteoarthritis glucosamine sulphate/hydrochloride

Received: 26 November 2018

PACS:	R195.1
	R684

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	He Xun
	Guo Jiayi
	Lü Shiwen

Cite this article:

He Xun,Guo Jiayi,Lü Shiwen. A Meta-analysis of sulphate/hydrochloride glucosamine for osteoarthritis[J]. journal1, 2019, 26(1): 5-9.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2019.01.002 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2019/V26/I1/5

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