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| Changes of hemoglobin in the treatment of moderate and severe traumatic brain injury by hyperbaric oxygenation combined with progesterone and prognostic relevance |
| Jin Menghao1,Wu Lijun2,Sun Mengfang1,Wang Feng1,Wu Tingqian1,Xu Qiang1 |
1 Department of Neurosurgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, 325000, China;
2 Department of Laboratory, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine |
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Abstract Objective To study the effects of hyperbaric oxygenation combined with progesterone on hemoglobin and prognosis in moderate and severe traumatic brain injury. Methods Ninety patients with moderate and severe traumatic brain injury (TBI) from January 2016 to June 2016 were randomly divided into three groups. Hyperbaric oxygenation, progesterone, and hyperbaric oxygenation combined with progesterone treatment were used respectively in three groups. We compared changes of progesterone, estradiol and testosterone in the serum, Glasgow coma (GCS) score, and Glasgow prognosis (GOS) score among groups. Results After the treatment, the levels of progesterone and estradiol in hyperbaric oxygenation combined with progesterone group were significantly higher than those in progesterone group and hyperbaric oxygenation group, while testosterone level was significantly lower than that in progesterone group and hyperbaric oxygenation group, with significant difference (P<0.05). After the treatment, the GCS score in hyperbaric oxygenation combined with progesterone group was significantly higher than that in progesterone group and hyperbaric oxygenation group, and the difference was significant (P<0.05). In the six-month follow-up, the GOS score in hyperbaric oxygenation combined with progesterone group was significantly higher than that in progesterone group and hyperbaric oxygenation group, with significant difference (P<0.05). Conclusion Hyperbaric oxygenation combined with progesterone can effectively improve the levels of progesterone and estradiol, decrease the testosterone level, and improve prognosis for the treatment of moderate and severe TBI.
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Received: 31 August 2017
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[1] 蒋天伟,杭春华.创伤性脑损伤中孕酮的应用研究进展[J].中华实验外科杂志,2016,33(3):851-854.
[2] 肖国民.创伤性脑损伤多效神经保护药物治疗研究进展[J].健康研究,2011,31(1):54-57.
[3] 郭丽君,荆淑云,韩峰连,等.颅脑创伤患者早期血清孕酮动态变化的临床意义探讨[J].中国医药指南,2014,12(36):151-152.
[4] 刘宇.2002—2006年住院病人疾病构成分析[J].中国医院统计,2007,14(4):361-362.
[5] 林明杰,邵剑波,吴清锋,等.武汉市332例儿童颅脑损伤的原因分析[J].中国医院统计,2014,21(6):432-434.
[6] KUMAR A, LOANE DJ. Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention[J]. Brain, behavior, and immunity,2012,26(8):1191-201.
[7] 董明昊,葛学诚,出良钊,等.创伤性脑损伤后性激素变化对预后的影响[J].中华创伤杂志,2014,30(9):887-889.
[8] 沈云龙,崔玉婷,李伟光,等.创伤性颅脑损伤患者急性期垂体前叶激素水平的变化及意义[J].广东医学,2015,36(23):3662-3665.
[9] Roof RL, Hall ED. Estrogen-related gender difference in survival rate and cortical blood flow after impact-acceleration head injury in rats[J]. Journal of neurotrauma, 2000,17(12):1155-69.
[10]吴华伟.高压氧辅助治疗重症脑创伤恢复期患者的临床疗效及对脑氧代谢的影响[J].实用心脑肺血管病杂志,2015,23(5):107-109.
[11]肖国民.黄体酮对颅脑损伤神经保护研究现状[J].中华神经外科杂志,2014,30(5): 530-533.
[12]HANSEN MB, OLSEN NV, HYLDEGAARD O. Combined administration of hyperbaric oxygen and hydroxocobalamin improves cerebral metabolism after acute cyanide poisoning in rats[J]. J Appl Physiol (1985), 2013,115(9):1254-1261.
[13]王冬梅,常杰,白云贤,等.急性颅脑损伤血清性激素水平变化与预后的研究[J].中华神经外科杂志,2014,30(7):715-717.
[14]王超,刘窗溪,熊云彪,等.成人创伤性脑损伤后垂体相关激素的变化及其临床意义[J].中华创伤杂志,2014,30(5):404-409.
[15]黄厚智,仝海波.创伤性脑损伤后神经内分泌变化的研究进展[J].中华临床医师杂志:电子版,2016,10(8):112-115.
[16]陶宁,何静.抗脑垂体抗体测定对急性脑损伤患者垂体功能评价的作用[J].重庆医学,2014,43(14):1789-1791.
[17]董明昊,葛学诚,出良钊,等.创伤性脑损伤后性激素变化对预后的影响[J].中华创伤杂志,2014,30(9):887-889.
[18]徐伟光,殷利明,赵展,等.脑损伤恢复期神经内分泌改变及临床意义[J].国际神经病学神经外科学杂志,2014,41(2):115-117.
[19]喻文,罗红敏.黄体酮治疗急性创伤性脑损伤:一项随机对照试验的系统评价[J].中华危重病急救医学,2015(11):898-898.
[20]梁观钦,蔡厚洪,郭汝翠,等.重型颅脑损伤中远期并发垂体功能低下的高危临床因素分析[J].神经损伤与功能重建,2015,10(6):554-556. |
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