子宫内膜癌辅助治疗模式的Meta分析

doi:10.3969/j.issn.1006-5253.2016.05.005

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Abstract Objective To review the effect and safety of chemotherapy alone or radiation alone in the treatment of endometrial cancer. Methods Databases of PubMed, Cochrane Library, Medline, Embase, Ovid, CBM, VIP, Wanfang, CNKI were searched, and randomized trials (RCT) of chemotherapy alone versus radiation alone for the treatment of endometrial cancer were gathered (from 2006 to 2016). Then the Meta-analysis was performed by using RevMan 5.2 software. Results Eight RCTs were included, involving 1 828 patients. Meta-analysis indicated that the differences of 5-year overall survival rate (RR＝0.92,95%CI (0.87,0.98), P=0.01), disease recurrence rate (RR＝1.15,95%CI (1.02,1.30), P=0.02), grade 3/4 thrombocytopenia (RR＝0.13,95%CI (0.07,0.27), P<0.000 01), grade 3/4 neutropenia (RR＝0.01,95%CI (0.00,0.03), P<0.000 01) between chemotherapy alone and radiation alone were significant. Conclusion Compared with postoperative radiotherapy, postoperative chemotherapy might improve the overall survival rate for patients with advanced stage endometrial cancer.

Key words： radiotherapy chemotherapy endometrial cancer adjuvant therapy Meta analysis

Received: 12 September 2016

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	Chen Qiaoying
	Jiang Bengui

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Chen Qiaoying,Jiang Bengui. Effectiveness of chemotherapy alone versus radiation alone in endometrial cancer Meta analysis of randomized controlled trials[J]. journal1, 2016, 23(5): 335-339.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2016.05.005 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2016/V23/I5/335

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