老年住院患者使用抗生素所致肾功能异常风险预测模型的构建

doi:10.3969/j.issn.1006-5253.2021.05.005

Abstract
Figure/Table
References (0)
Related Citation (4)

Download: PDF (1133 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To construct a risk prediction model for abnormal renal function caused by antibiotics in elderly hospitalized patients. Methods A retrospective analysis was conducted on the clinical data of 208 elderly inpatients in a tertiary hospital in Zhejiang Province from March 2017 to June 2019. Single factor and logistic regression were used to analyze the independent risk factors of renal dysfunction caused by antibiotics in elderly inpatients. And a risk prediction model was established for abnormal renal function caused by antibiotics in elderly hospitalized patients. Results There were statistical differences in age, abnormal thyroid function, history of diabetes, type of antibiotics, history of hypertension, and combined antibiotics between patients with abnormal renal function and those without abnormal renal function (P<0.05). Logistic regression analysis showed that age≥65 years old (OR=3.915, 95%CI: 1.589-9650), abnormal thyroid function (OR=4.892, 95%CI: 2.000-11.965), a history of diabetes (OR=5.277,95%CI:2.014-13.824) use of aminoglycoside antibiotics (OR=3.975, 95%CI:1.617-9.773), a history of hypertension (OR=3.270, 95%CI: 1.387-7.711), and combined antibiotics (OR=3.197, 95%CI: 1.373-7.442) were independent risk factors for renal dysfunction due to antibiotic use in elderly hospitalized patients (P<0.05). The established nomogram model for predicting the abnormal renal function caused by antibiotics in elderly hospitalized patients and the verification resultsshowed that the predicted value was basically consistent with the measured value. The ROC curve of the abnormal renal function risk nomogram had an AUC of 0.848 (95% CI ：0.812-0.884), suggesting that the predictionaccuracy of the model was acceptable. Conclusion Age≥65 years old, abnormal thyroid function, history of diabetes, use of aminoglycoside antibiotics, history of hypertension, and combined antibiotics are independent risk factors for renal dysfunction caused by antibiotics in elderly hospitalized patients, and the above six factors can be combined clinically to take targeted measures to prevent and treat renal dysfunction.

Key words： elderly hospitalized patient antibiotics abnormal renal function nomgram prediction model

Received: 15 May 2021

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Zheng Jia
	Ke Meifang
	Xu Tianyan

Cite this article:

Zheng Jia,Ke Meifang,Xu Tianyan. Construction of risk prediction model for abnormal renal function caused by antibiotics in elderly inpatients[J]. journal1, 2021, 28(5): 405-408.

URL:

http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2021.05.005 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2021/V28/I5/405

［1］李睿旻，孙晓红，杨樟卫，等．区域多中心重点监控药物目录的遴选方法及其监管策略［J］．药学实践杂志，2019，37(6)：548-551． 
［2］张帆，李航，刘悦，等．沈阳市某三甲中医院急性支气管炎中药及抗生素使用处方分析研究［J］．辽宁中医杂志，2019，46(7)：1356-1362．
［3］张志禹，陈贺杰，黄育金，等．航空兵某部门诊抗生素使用情况分析［J］．人民军医，2019，62(1)：41-46． 

［4］刘昌孝. 全球关注:重视抗生素发展与耐药风险的对策［J］. 中国抗生素杂志,2019,44(1):1-8.

［5］HU F, SUN L. Recognizable type of pituitary, heart, kidney and skeletal dysplasia mostly caused by SEMA3A mutation: A case report［J］. World J Clin Cases, 2019, 7(20):3310-3315. 
［6］陶兴茹，陈海燕，裴保方，等．新生儿万古霉素不同血药浓度对肾功能的影响［J］．中国抗生素杂志，2019，44(5)：628-631．

［7］PATEK T M, TENG C W, KENNEDY K E, et al. Comparing acute kidney injury reports among antibiotics: A pharmacovigilance study of the FDA adverse event reporting system (FAERS)［J］. Drug Saf, 2020, 43(1):17-22. 
［8］ÇAK1R S Ç, ÇELEBI S, ÕZKAN H, et al. Results of the use of micafungin in newborns［J］. Mikrobiyol Bul, 2019, 53(1):70-80. 
［9］《抗菌药物临床应用指导原则》修订工作组. 抗菌药物临床应用指导原则:2015年版［M］.北京：人民卫生出版社, 2015.
［10］程庆砾．重视衰弱对老年慢性肾脏病的影响［J］．肾脏病与透析肾移植杂志，2019，28(6)：544-545． 

［11］王珊珊,王颖,许杰,等.亚临床甲状腺功能减退症与2型糖尿病肾功能损伤的相关性研究［J］.国际内分泌代谢杂志,2019,39(6):368-372.
［12］张敬林，周玉杰，王悦，等．冠心病合并2型糖尿病患者肾功能下降危险因素分析［J］．心肺血管病杂志，2019，38(2)：128-132． 
［13］冯婷婷，王佳贺．老年肾脏功能与抗生素选择［J］．实用老年医学，2018，32(3)：209-211． 
［14］陈伟，张涛．老年高血压患者24小时收缩压变化与肾功能的关系研究［J］．中华老年心脑血管病杂志，2019，21(1)：22-25． 
［15］王欣,闫素英,蔡晧东.关注老年患者的用药错误［J］.药物不良反应杂志,2020,22(11):609-612.
［16］姬忠贺，于洋，刘刚，等．肿瘤细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜转移的预后列线图构建与验证［J］．中华普通外科杂志，2019，34(10)：833-836.
［17］黄欢欢,郑菊芳,余善招.急性脑梗死鼻饲患者腹泻风险预测模型的构建［J］.中国医院统计,2021,28(2):139-142.